190586-91-5Relevant academic research and scientific papers
Novel Hybrid Molecules of Epinastine and Mefenamic Acid for Bioactive Assessment as Potential Anti-inflammatory Agents
Lee, Ju Mi,Damodar, Kongara,Lee, Yeontaek,Woo, Hyeong Ryeol,Suh, Hong Won,Jeon, Sung Ho,Lee, Jeong Tae
, p. 444 - 449 (2020)
A set of novel epinastine (1) and mefenamic acid (2) hybrids (3–7) tethered via amide bond were designed and synthesized with the artistry of molecular hybridization. Then their inhibitory effect on nitric oxide (NO) production in LPS-induced RAW-264.7 ma
Synthetic studies towards N-substituted 3-vinyl-4-piperidineacetic acid derivatives
Johnson, David A.,Gribble, Gordon W.
, p. 178 - 195 (2019/05/15)
The synthesis and full characterization of two new (E)-2-butenyl)-5-amino-2-pentenoates, (Z)-4-[N-(3-buten-1-yl)benzamido]-2-buten-1-ol, and (Z)-1-chloro-4-[N-(3-buten-l-yl)benzamido]-2-butene are reported. These were designed as substrates for a projected thermal ene cyclization leading to the N-substituted 3-vinyl-4-piperidineacetic acid scaffold. Although conditions for this ene-cyclization have not yet been uncovered, the ease of preparation of these ene-cyclization substrates gives promise for their future use.
Catalytic Synthesis of N-Heterocycles via Direct C(sp3)-H Amination Using an Air-Stable Iron(III) Species with a Redox-Active Ligand
Bagh, Bidraha,Broere, Dani?l L. J.,Sinha, Vivek,Kuijpers, Petrus F.,Van Leest, Nicolaas P.,De Bruin, Bas,Demeshko, Serhiy,Siegler, Maxime A.,Van Der Vlugt, Jarl Ivar
supporting information, p. 5117 - 5124 (2017/05/04)
Coordination of FeCl3 to the redox-active pyridine-aminophenol ligand NNOH2 in the presence of base and under aerobic conditions generates FeCl2(NNOISQ) (1), featuring high-spin FeIII and an NNOISQ radical ligand. The complex has an overall S = 2 spin state, as deduced from experimental and computational data. The ligand-centered radical couples antiferromagnetically with the Fe center. Readily available, well-defined, and air-stable 1 catalyzes the challenging intramolecular direct C(sp3)-H amination of unactivated organic azides to generate a range of saturated N-heterocycles with the highest turnover number (TON) (1 mol% of 1, 12 h, TON = 62; 0.1 mol% of 1, 7 days, TON = 620) reported to date. The catalyst is easily recycled without noticeable loss of catalytic activity. A detailed kinetic study for C(sp3)-H amination of 1-azido-4-phenylbutane (S1) revealed zero order in the azide substrate and first order in both the catalyst and Boc2O. A cationic iron complex, generated from the neutral precatalyst upon reaction with Boc2O, is proposed as the catalytically active species.
Depsipeptides containing non-natural amino acids
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, (2008/06/13)
A depsipeptide containing a non-natural amino acid(s) having the formula (1) wherein R1represents a C5-C20alkyl group and others; R2represents —O—CO—CH(R5)—X—CH(R6)—NH— (wherein X represent
