1906-95-2

Usage

Uses

Used in Organic Chemical Synthesis:
(5-BROMOPENTYL)MALONIC ACID DIETHYL ESTER is used as a reagent in organic chemical synthesis for the preparation of various organic compounds. Its unique structure and reactivity make it a valuable component in the creation of a wide range of chemical products.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (5-BROMOPENTYL)MALONIC ACID DIETHYL ESTER is utilized as an intermediate. Its role in the synthesis of pharmaceuticals is crucial, as it contributes to the development of new drugs and medicines that can address various health conditions and diseases.
Used in Chemical Research:
(5-BROMOPENTYL)MALONIC ACID DIETHYL ESTER is also employed in chemical research as a tool to explore new reactions and mechanisms, further expanding the understanding of organic chemistry and potentially leading to the discovery of novel applications and products.

InChI:InChI=1/C12H21BrO4/c1-3-16-11(14)10(12(15)17-4-2)8-6-5-7-9-13/h10H,3-9H2,1-2H3

Upstream product

• 111-24-0 1,5-dibromo-pentane 
• 996-82-7 sodium diethylmalonate 
• 105-53-3 diethyl malonate 

Downstream Products

• 1139-13-5 diethyl cyclohexane-1,1-dicarboxylate 
• 30515-28-7 7-bromoheptanoic acid 
• 25462-23-1 2-pentylpropane-1,3-diol 
• 115694-04-7 (bromo-5 pentyl)-2 propanediol-1,3 
• 23433-05-8 1,3-octane diol 
• 34546-57-1 2-(6-methoxycarbonylhexyl)cyclopent-2-en-1-one 
• 5288-67-5 2-(6-carboxyhexyl)cyclopentanone 

Relevant academic research and scientific papers

The synthesis of new potential photosensitizers. 1. Mono-carboxylic acid derivatives of tetraphenylporphyrin

A series of mono-alkylcarboxylic acid derivatives of tetraphenylporphyrin have been prepared. All the porphyrins were completely characterized by use of mass, 1H NMR, UV-visible, and fluorescence spectroscopy. Experimental log P were determined

Thermal properties of liquid-crystalline diols and corresponding bis-urethanes with mesogenic groups of various structures in side chains

The liquid-crystalline dials with mesogenic groups of different structures were synthetized and their temperature behavior and existence of mesophases were determined. These compounds were also reacted with phenylisocyanate to form bis-urethanes at the ra

Intramolecular photoreactions of phthalimide-alkene systems. Macrocyclic synthesis through the remote Paterno-Buchi reaction of phthalimide with indole derivatives

Upon irradiation, phthalimide-indole in bichromophoric systems underwent intramolecularly remote Paterno-Buchi reaction to give oxeto[2,3-b]indole derivatives containing macrocycles, in competition with Norrish type II reaction.

Syntheses and Properties of New Liquid-Crystalline Polymers Having 1,3,2-Dioxaborinane Pendants

Polyacrylates and polymethacrylates having various 1,3,2-dioxaborinane derivatives as pendants have been synthesized and demonstrated to form chiral smectic C and/or smectic A phases which are more stable than those formed by the corresponding monomes.The

Synthese de l'acide (dimercapto-1,3 propyl-2)-15 pentadecanoique, complexant potentiel du 99mTc

The synthesis of 15-(1,3-dimercapto 2-propyl) pentadecanoic acid was performed in ten steps.One of these steps is the condensation of (5) with 7-bromoheptanoic acid.It is achieved in liquid ammonia or in a HMPA-THF medium with yields higher than 50 percent.In the second case a-5 bromoacid-ratio of 2.1 (slightly superior to the stoichiometry) is sufficient to obtain these yields, whereas in ammonia, the ratio must be higher than 5 and is therefore clearly unfavourable.The reaction times are also much longer in ammonia.The obtention of 5 from diethyl (6-bromohexyl) malonate 2 implies the reduction of ester functions and the substitution of Br by the ethynyl group.The optimal conditions and the sequence of these two steps have been determined.

PRACTICAL SYNTHESIS OF 2-(6'-METHOXYCARBONYLHEXYL)CYCLOPENT-2-EN-1-ONE (PROSTAGLANDIN SYNTHON)

2-(6'-Methoxycarbonylhexyl)cyclopentanone was obtained by alkylation of the 2-(ethoxycarbonyl)cyclopentanone potassium salt with diethyl 5-bromopentylmalonate followed by acid cleavage of the obtained triester and esterification.Its bromination with copper bromide and dehydrobromination with collidine lead to 2-(6'-methoxycarbonylhexyl)cyclopent-2-en-1-one (a known prostaglandin synthon) with an overall yield of 28percent.The use of molecular bromine for bromination leads to the production of the 5-bromo analog of the synthon.