19071-54-6

Usage

Chemical compound

1-(alpha-(Hydroxymethyl)phenethyl)-3-phenylurea

Application

Fungicide in agricultural use

Group

Phenylurea fungicides

Effective against

Wide range of fungal diseases, particularly those affecting fruits and vegetables

Mode of action

Inhibits the enzyme responsible for the synthesis of fungal cell walls

Impact on fungi

Leads to the death of the fungus

Toxicity to mammals

Low toxicity

Environmental impact

Considered environmentally friendly due to low impact on non-target organisms

Safety measures

Handle with caution and follow appropriate safety measures when using

InChI:InChI=1/C16H18N2O2/c19-12-15(11-13-7-3-1-4-8-13)18-16(20)17-14-9-5-2-6-10-14/h1-10,15,19H,11-12H2,(H2,17,18,20)

Upstream product

• 62-53-3 aniline 
• 63-91-2 L-phenylalanine 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 138088-28-5 (S)-3-phenyl-2-(3-phenyl-ureido)-propionic acid methyl ester 
• 3182-95-4 L-Phenylalaninol 
• 103-71-9 phenyl isocyanate 

Relevant academic research and scientific papers

Microwave-assisted synthesis of bidentate chiral unsymmetrical urea derivatives of p-tert-butylcalix[4]arene and their anion recognition properties

Four new derivatives of p-t-butylcalix[4]arene containing two (1,3-distal) chiral unsymmetrical urea moieties at the lower rim were synthesised in four steps. Their anion recognition properties toward MeCO2-, H2PO4-, NOsu

Synthesis of novel chiral cholic acid-based molecular tweezers containing unsymmetrically disubstituted urea units using microwave irradiation

An efficient procedure has been developed for the synthesis of new chiral cholic acid molecular tweezer artificial receptors by linking an unsymmetrically disubstituted urea to methyl deoxycholate via a carbonate chain using microwave irradiation. The structures of these new receptors were confirmed by 1H NMR, IR, MS spectra and elemental analysis. Their binding properties were examined by UV-Vis spectra titration. The preliminary results indicate that these molecular tweezers not only recognised anions, but also showed good enantioselectivity for D-amino acid methyl esters.

Solvent-free synthesis of novel chiral unsymmetrical urea molecular tweezers under microwave irradiation

Seven novel chiral unsymmetrical urea molecular tweezers based on 1, 3-phenoxyacetic acid have been designed and synthesised using solid K 2CO3 as supporter in the solvent-free conditions under microwave irradiation. This method is simple, fast, efficient and eco-friendly. The structures of target compounds were characterised by IR, 1H NMR, MS spectra and elemental analyses and their molecular recognition properties were investigated by UV-Vis spectral titration. The preliminary results indicated that these molecular tweezers possess good selectivity for D/L amino acid methyl esters and some anions.

The synthesis of novel chiral cholic acid-based molecular clefts containing unsymmetrically disubstituted urea unit

A novel type of chiral molecular clefts has been designed and synthesized by linking an unsymmetrically disubstituted urea to methyl deoxycholate via a carbonate chain. The structures of these new receptors 3a-d were confirmed by 1H NMR, IR, MS

Investigation of the Mitsunobu reaction of N-(2-hydroxyethyl)-N'- phenyl-ureas

The Mitsunobu reaction of N-(2-hydroxyethyl)-ureas 1 using PPh3 and EtO2CN=NCO2Et led to the mixture of N- and O-alkylation products or a single isomer depending on the substrates.