190711-23-0Relevant academic research and scientific papers
Transformations of 1,2,4-triazines in reactions with nucleophiles: V. SNH and ipso-substitution in the synthesis and transformations of 5-cyano-1,2,4-triazines
Kozhevnikov,Kozhevnikov,Kovalev,Rusinov,Chupakhin,Aleksandrov
, p. 744 - 750 (2007/10/03)
The scope of functionalization of 1,2,4-triazines can be considerably extended via successive nucleophilic substitution of hydrogen (S NH) and ipso-substitution. A convenient procedure has been developed for direct cyanation of 1,2,4-triazine 4-oxides with acetone cyanohydrin in the presence of triethylamine. The cyano group in the resulting 5-cyano-1,2,4-triazines is readily replaced by reactions with various aliphatic alcohols and amines.
