190712-45-9

Basic information

• Product Name: [(1S,2R)-1-Benzyl-3-(2-tert-butylcarbamoyl-phenylamino)-2-hydroxy-propyl]-carbamic acid tert-butyl ester
• Synonyms: [(1S,2R)-1-Benzyl-3-(2-tert-butylcarbamoyl-phenylamino)-2-hydroxy-propyl]-carbamic acid tert-butyl ester
• CAS NO: 190712-45-9
• Molecular Weight: 455.597
• Mol File: 190712-45-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [(1S,2R)-1-Benzyl-3-(2-tert-butylcarbamoyl-phenylamino)-2-hydroxy-propyl]-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [(1S,2R)-1-Benzyl-3-(2-tert-butylcarbamoyl-phenylamino)-2-hydroxy-propyl]-carbamic acid tert-butyl ester(190712-45-9)
• EPA Substance Registry System: [(1S,2R)-1-Benzyl-3-(2-tert-butylcarbamoyl-phenylamino)-2-hydroxy-propyl]-carbamic acid tert-butyl ester(190712-45-9)

Safety Data

• Hazardous Substances Data: 190712-45-9(Hazardous Substances Data)

Upstream product

• 103127-52-2 ((S)-1-benzylallyl)carbamic acid tert-butyl ester 
• 152303-48-5 [(1S,2S)-1-Benzyl-3-(2-tert-butylcarbamoyl-phenylamino)-2-hydroxy-propyl]-carbamic acid tert-butyl ester 
• 1203-89-0 2-amino-N-(1,1-dimethylethyl)benzamide 
• 98760-08-8 (1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester 
• 149451-80-9 (2S,3S)-3-(t-butoxycarbonylamino)-4-phenylbutane-1,2-diol 

Relevant articles and documents

A convenient synthesis of 1-(S)-[1'-(S)-(t-butyloxycarbonylamino)-2'- phenylethyl]oxirane. A useful building block in the synthesis of HIV protease inhibitors

A new short route to epoxide 6b, a pivotal intermediate for the preparation of hydroxyethylamine dipeptide isosteres has been developed. Opening of the epoxide by anthranilic acid, followed by extensions in the P2/P3-region gave the target compounds which were evaluated as HIV-1 protease inhibitors.