152303-48-5

Basic information

• Product Name: [(1S,2S)-1-Benzyl-3-(2-tert-butylcarbamoyl-phenylamino)-2-hydroxy-propyl]-carbamic acid tert-butyl ester
• Synonyms: [(1S,2S)-1-Benzyl-3-(2-tert-butylcarbamoyl-phenylamino)-2-hydroxy-propyl]-carbamic acid tert-butyl ester
• CAS NO: 152303-48-5
• Molecular Weight: 455.597
• Mol File: 152303-48-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [(1S,2S)-1-Benzyl-3-(2-tert-butylcarbamoyl-phenylamino)-2-hydroxy-propyl]-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [(1S,2S)-1-Benzyl-3-(2-tert-butylcarbamoyl-phenylamino)-2-hydroxy-propyl]-carbamic acid tert-butyl ester(152303-48-5)
• EPA Substance Registry System: [(1S,2S)-1-Benzyl-3-(2-tert-butylcarbamoyl-phenylamino)-2-hydroxy-propyl]-carbamic acid tert-butyl ester(152303-48-5)

Safety Data

• Hazardous Substances Data: 152303-48-5(Hazardous Substances Data)

Upstream product

• 1203-89-0 2-amino-N-(1,1-dimethylethyl)benzamide 
• 98760-08-8 (2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane 

Downstream Products

• 190712-45-9 [(1S,2R)-1-Benzyl-3-(2-tert-butylcarbamoyl-phenylamino)-2-hydroxy-propyl]-carbamic acid tert-butyl ester 

Relevant articles and documents

A convenient synthesis of 1-(S)-[1'-(S)-(t-butyloxycarbonylamino)-2'- phenylethyl]oxirane. A useful building block in the synthesis of HIV protease inhibitors

A new short route to epoxide 6b, a pivotal intermediate for the preparation of hydroxyethylamine dipeptide isosteres has been developed. Opening of the epoxide by anthranilic acid, followed by extensions in the P2/P3-region gave the target compounds which were evaluated as HIV-1 protease inhibitors.