1203-89-0

Basic information

• Product Name: 2-AMINO-N-TERT-BUTYLBENZAMIDE
• Synonyms: BENZAMIDE, 2-AMINO-N-(1,1-DIMETHYLETHYL)-;BUTTPARK 51\02-32;AKOS BBB/061;2-AMINO-N-TERT-BUTYLBENZAMIDE;ZERENEX E/5016844;2-[(tert-Butyl)carbamoyl]aniline, 2-{[(tert-Butyl)amino]carbonyl}aniline
• CAS NO: 1203-89-0
• Molecular Formula: C₁₁H₁₆N₂O
• Molecular Weight: 192.26
• Mol File: 1203-89-0.mol
• Article Data: 15

Chemical Properties

• Melting Point: 124-125°C
• Boiling Point: 359.6 °C at 760 mmHg
• Flash Point: 171.3 °C
• Appearance: /
• Density: 1.058 g/cm³
• Vapor Pressure: 2.36E-05mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: 2-8°C
• PKA: 14.72±0.46(Predicted)
• CAS DataBase Reference: 2-AMINO-N-TERT-BUTYLBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-N-TERT-BUTYLBENZAMIDE(1203-89-0)
• EPA Substance Registry System: 2-AMINO-N-TERT-BUTYLBENZAMIDE(1203-89-0)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 1203-89-0(Hazardous Substances Data)

Usage

General Description

2-AMINO-N-TERT-BUTYLBENZAMIDE is a chemical compound that belongs to the class of organic compounds known as benzamides. It is a white crystalline solid at room temperature and is typically used as an intermediate in the synthesis of other compounds. This chemical has the molecular formula C11H16N2O and a molecular weight of 192.26 g/mol. It is also known by its IUPAC name N-tert-butyl-2-aminobenzamide and is commonly used in the pharmaceutical and agrochemical industries for various applications.

InChI:InChI=1/C11H16N2O/c1-11(2,3)13-10(14)8-6-4-5-7-9(8)12/h4-7H,12H2,1-3H3,(H,13,14)

Upstream product

• 118-92-3 anthranilic acid 
• 91-56-5 indole-2,3-dione 
• 1092075-56-3 2-amino-N-(tert-butyl)-N-[(5-methyl-2-furyl)methyl]benzamide 
• 610-15-1 2-nitrobenzamide 
• 55668-30-9 2-aminobenzoic acid 2,5-dioxopyrrolidin-1-yl ester 
• 75-64-9 tert-butylamine 
• 118-48-9 isatoic anhydride 

Downstream Products

• 616890-56-3 3-tert-butyl-1-(4-methoxybenzyl)-1,2,3,4-tetrahydroquinazoline-2,4-dione 
• 616890-30-3 1-(4-methoxybenzyl)-1,2,3,4-tetrhydroquinazoline-2,4-dione 
• 616890-29-0 N-tert-butyl-N′-(methoxycarbonyl)-2-aminobenzamide 
• 190712-45-9 [(1S,2R)-1-Benzyl-3-(2-tert-butylcarbamoyl-phenylamino)-2-hydroxy-propyl]-carbamic acid tert-butyl ester 
• 152303-48-5 [(1S,2S)-1-Benzyl-3-(2-tert-butylcarbamoyl-phenylamino)-2-hydroxy-propyl]-carbamic acid tert-butyl ester 

Relevant articles and documents

Green synthesis of novel phosphonate derivatives using ultrasonic irradiation

[Figure not available: see fulltext.] A novel and efficient procedure for the generation of quinazolinone phosphonate derivatives employing the reaction of euparin, isatin or its derivatives, primary amines, dialkyl acetylenedicarboxylates, trimethyl phosphite or triphenyl phosphite, and acidic solution of hydrogen peroxide in aqueous media at ambient temperature under ultrasonic irradiation was developed. Without ultrasonic irradiation, the reaction does not proceed and agitation of the reaction mixture is difficult. Some advantages of this procedure are: short time of reaction, high yields of products, easy isolation of products.

1,3,4-OXADIAZOLE HOMOPHTHALIMIDE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to novel compounds having a histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, a medicinal use thereof, and a method for preparing the same. The novel compounds according to the present invention, stereoisomers thereof or pharmaceutically acceptable salts thereof have the histone deacetylase 6 (HDAC6) inhibitory activity, and are effective in preventing or treating HDAC6-related diseases, comprising infectious diseases; neoplasm; endocrinopathy; nutritional and metabolic diseases; mental and behavioral disorders; neurological diseases; eye and ocular adnexal diseases; circulatory diseases; respiratory diseases; digestive diseases; skin and subcutaneous tissue diseases; musculoskeletal system and connective tissue diseases; and teratosis or deformities, or chromosomal aberration.

I2-catalyzed aerobic oxidative C(sp3)-H amination/C-N cleavage of tertiary amine: Synthesis of quinazolines and quinazolinones

An iodine-catalyzed oxidative C(sp3)-H amination/C-N cleavage of tertiary amines couducted under an oxygen atmosphere has been developed and affords a route to quinazolines and quinazolinones in good to excellent yields via a domino ring annulation. The method is metal-free, peroxide-free, and operationally simple to implement with a wide scope of substrates and represents a new avenue for multiple C-N bond formations.