190730-41-7

Basic information

• Product Name: 1-Piperidinebutanoic acid, 4-[(4-chlorophenyl)-2-pyridinylmethoxy]-, (R)-
• Synonyms: 1-Piperidinebutanoic acid, 4-[(4-chlorophenyl)-2-pyridinylmethoxy]-, (R)-;1-Piperidinebutanoic acid, 4-[(R)-(4-chlorophenyl)-2-pyridinylmethoxy]-;(R)-Bepotastine
• CAS NO: 190730-41-7
• Molecular Formula: C21H25 Cl N2 O3
• Molecular Weight: 388.89
• Mol File: 190730-41-7.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Piperidinebutanoic acid, 4-[(4-chlorophenyl)-2-pyridinylmethoxy]-, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinebutanoic acid, 4-[(4-chlorophenyl)-2-pyridinylmethoxy]-, (R)-(190730-41-7)
• EPA Substance Registry System: 1-Piperidinebutanoic acid, 4-[(4-chlorophenyl)-2-pyridinylmethoxy]-, (R)-(190730-41-7)

Safety Data

• Hazardous Substances Data: 190730-41-7(Hazardous Substances Data)

Usage

Enantiomer

(R)form, indicating the specific three-dimensional arrangement of the molecule

Rotating plane-polarized light

The (R)-enantiomer rotates plane-polarized light in a specific direction, which is important in the field of optical activity

Piperidine ring

A nitrogen-containing six-membered aromatic ring, which is a common structural motif in many pharmaceuticals

Butanoic acid group

A four-carbon carboxylic acid, contributing to the acidic properties of the compound

4-[(4-chlorophenyl)-2-pyridinylmethoxy] substituent

A functional group attached to the piperidine ring, which includes a chlorine atom and a pyridine ring connected through an oxygen atom

Potential applications

This compound may have potential applications in pharmaceuticals, as compounds with similar structures have been studied for their biological activities, such as antipsychotic and anti-inflammatory properties

Further research

More research is needed to fully understand the specific properties and potential uses of this particular compound, including its pharmacokinetics, pharmacodynamics, and safety profile.

Upstream product

• 122368-54-1 4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine 
• 1560797-65-0 (RS)-4-[4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidino]butyric acid D-menthyl ester 
• 1560797-70-7 (S)-4-{4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidino}butyric acid D-menthyl ester L-tartrate 
• 1560797-69-4 (S)-4-[4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidino] butyric acid D-menthyl ester 
• 4045-22-1 N-acetyl-4-hydroxypiperidine 
• 5382-16-1 4-HYDROXYPIPERIDINE 
• 207726-35-0 4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidine-1-carboxylic acid ethyl ester 
• 27652-89-7 (4-chlorophenyl)-2-pyridylmethanol 
• 190786-43-7 4-(4-[(4-chlorophenyl)-pyridin-2-ylmethoxy]piperidin-1-yl)butanoic acid 
• 142404-69-1 2-[chloro(4-chlorophenyl)methyl]pyridine 
• 125602-67-7 ethyl 3-[4-[(4-chlorophenyl)-pyridin-2-ylmethoxy]-1-piperidyl]propionate 
• 6318-51-0 2-(4-chlorobenzoyl)pyridine 
• 301673-14-3 tert-butyl 4-iodopiperidine-1-carboxylate 

Relevant articles and documents

Total synthesis method of bestatin

The method comprises the following steps: (4 - chlorophenyl) (2 - pyridyl) - methanol as a starting raw material, and sequential addition reaction. Examples of the etherification reaction include a deprotection reaction, a chiral resolution, a condensation reaction, a hydrolysis reaction, and the like. The synthesis method has the advantages of cheap and easily available raw materials, no need of expensive chiral catalysts, simpler synthesis method, mild conditions, less side reactions and low cost.

Identification, Characterization and HPLC Quantification of Process-Related Impurities in Bepotastine Besilate Bulk Drug

Bepotastine besilate (here after referred to as BTST), chemically known as ({d(S)4[4[(4chlorophenyl) (2pyridyl) methoxy] piperidino} butyric acid monobenzene sulphonate), is a second-generation antihistamine drug. To the best of our knowledge, no studies concerning the isolation or identification of process-related impurities have been reported so far. The current study reports the development and validation of a stability-indicating RP-HPLC method for the separation and identification of 5 potential impurities in bepotastine besilate. In this experiment, the structures of 3 process-related impurities were found to be new compounds. They were characterized and confirmed by NMR and MS spectroscopy analyses. These 3 new compounds were proposed to be (S)-4-[(phenyl)-2-pyridinylmethoxy]-1-piperidinebutanoic acid,(Imp-A); 4-[(S)-(4-chlorophenyl)-2-pyridinylmethoxy]-1- piperidinebutyric acid, N-oxide (Imp-B) and (S)-4-[(4- chlorophenyl)-2-pyridinylmethoxy]-1-piperidylethane (Imp-C). In addition, an efficient optimized chromatographic method was performed on a Shimadzu Inertsil C8-3 column (150 mm×4.6 mm, 3 μm) to separate and quantify these 5 impurities. It was using 15 mmol ammonium formate buffer in water (pH adjusted to 3.8 with formic acid) and acetonitrile as the mobile phase in gradient mode. The method was developed to separate and quantify these 5 impurities obtained in the range of 0.05-0.75 μg/mL. It was validated and proven to be selective, accurate and precise and suitable. It is the first publication of identification and characterization data of the 3 new compounds. It is also the first effective HPLC method for separation and quantification of all of process-related impurities in bepotastine besilate.