19079-11-9

Usage

Uses

Used in Pharmaceutical Research:
2,3-Dihydro-2-methyl-3-methylenepyrazino[1,2-a]indole-1,4-dione is used as a compound of interest in pharmaceutical research for its potential pharmacological properties. It is being studied for its effects on the central nervous system, which could lead to the development of new drugs targeting neurological conditions.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2,3-Dihydro-2-methyl-3-methylenepyrazino[1,2-a]indole-1,4-dione is used as a starting point for the synthesis of new drug candidates. Its unique structure and potential biological activities make it a valuable component in the search for novel therapeutic agents.

InChI:InChI=1/C13H10N2O2/c1-8-12(16)15-10-6-4-3-5-9(10)7-11(15)13(17)14(8)2/h3-7H,1H2,2H3

Upstream product

• 77920-71-9 N-methylindole-2-carboxamide 
• 5704-66-5 pyruvoyl chloride 
• 3770-50-1 2-carbethoxyindole 
• 67-99-2 gliotoxin 

Relevant academic research and scientific papers

The Biosynthetic Incorporation of Phenylalanine into Gliotoxin

When mixtures of DL--m-tyrosine and DL-phenylalanine were fed to cultures of Gliocladium deliquescens good incorporation (4.9 and 1.6percent in separate experiments) of (14)C and negligible incorporation (ca. 0.04percent) of (3)H into the derived gliotoxin (2) was observed.Incorporation of DL--, DL--, and L--phenylalanine into gliotoxin occured without loss of tritium.Degradation of the gliotoxin gave, in each case, bis(anhydro-dethio)gliotoxin (3) and dehydrogliotoxin (4) having a tritium content indicating that the incorporation of phenylalanine had occured without migration of tritium.These results, taken together, show that neither m-tyrosine (3'-hydroxyphenylalanine) nor any other hydroxybenzene derivative can be an obligatory intermediate on the biosynthetic pathway from phenylalanine to gliotoxin.The possible involvement of arene oxides in gliotoxin biosyhthesis is discussed.

Synthesis of dehydroamino acids and didehydrodioxopiperazines and their conversion into α-mercapto-α-amino acid derivatives

A synthesis of α,β-dehydroamino acid derivatives 12 is described, which is of possible general applicability and might be useful for the preparation of peptides which have such a moiety in their sequence.I addition, several didehydrodioxopiperazines (13-1