Cas 190835-45-1,3-Benzyl-1-benzyloxymethyl-2,2-dioxo-2,3-dihydro-1H-2λ<sup>6</sup>-benzo[1,2,6]thiadiazin-4-one

190835-45-1

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Basic information

Product Name: 3-Benzyl-1-benzyloxymethyl-2,2-dioxo-2,3-dihydro-1H-2λ⁶-benzo[1,2,6]thiadiazin-4-one
Synonyms: 3-Benzyl-1-benzyloxymethyl-2,2-dioxo-2,3-dihydro-1H-2λ⁶-benzo[1,2,6]thiadiazin-4-one
CAS NO:190835-45-1
Molecular Formula:
Molecular Weight: 408.478
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 3-Benzyl-1-benzyloxymethyl-2,2-dioxo-2,3-dihydro-1H-2λ⁶-benzo[1,2,6]thiadiazin-4-one(CAS DataBase Reference)
NIST Chemistry Reference: 3-Benzyl-1-benzyloxymethyl-2,2-dioxo-2,3-dihydro-1H-2λ⁶-benzo[1,2,6]thiadiazin-4-one(190835-45-1)
EPA Substance Registry System: 3-Benzyl-1-benzyloxymethyl-2,2-dioxo-2,3-dihydro-1H-2λ⁶-benzo[1,2,6]thiadiazin-4-one(190835-45-1)

Safety Data

Hazard Codes: N/A
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Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 190835-45-1(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 190835-45-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,0,8,3 and 5 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 190835-45:
(8*1)+(7*9)+(6*0)+(5*8)+(4*3)+(3*5)+(2*4)+(1*5)=151
151 % 10 = 1
So 190835-45-1 is a valid CAS Registry Number.

190835-45-1Upstream product

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190835-45-1Relevant academic research and scientific papers

Benzothiadiazine dioxide acyclonucleosides as lead compounds for the development of new agents against human cytomegalovirus and varicella-zoster virus infections

Martinez,Esteban,De Clercq

, p. 1031 - 1032 (1997)

The first acyclonucleosides derived from 2,1,3-benzothiazine dioxides were synthesized. From their antiviral activity evaluation results these compounds might be considered as new leads in the search for inhibitors of human cytomegalovirus (CMV) and varicella-zoster virus (VZV) infections.

Novel potential agents for human cytomegalovirus infection: Synthesis and antiviral activity evaluation of benzothiadiazine dioxide acyclonucleosides

Martinez, Ana,Esteban, Ana I.,Castro, Ana,Gil, Carmen,Conde, Santiago,Andrei, Graciela,Snoeck, Robert,Balzarini, Jan,De Clercq, Erik

, p. 1145 - 1150 (2007/10/03)

The first acyclonucleosides based on the benzothiadiazine dioxide system were synthesized following the silylation procedure. Several acyclic moieties, including acetoxyethoxymethyl, benzyloxymethyl, and propargyloxymethyl groups, were introduced. Two synthetic strategies were designed to selectively obtain the N-1 or N-3 derivatives. Lipase-mediated deacylation was used for the deprotection of the acyclonucleosides. Some of the benzothiadiazine dioxide acyclonucleosides, in particular 16, proved active against human cytomegalovirus (CMV) at concentrations slightly higher than that found for ganciclovir [50% inhibitory concentration (IC50) = 3.5- 3.7 μg/mL, cytotoxicity (CC50) ≥ 40 μg/mL, MCC = 20 μg/mL]. Additionally, compound 16 inhibited the replication of human immunodeficiency virus type 1 (HIV-1) and HIV-2 in CEM cells at concentrations that were 5- fold lower than its cytotoxic concentration.

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