7708-28-3

Upstream product

• 109-87-5 Dimethoxymethane 
• 108-24-7 acetic anhydride 
• 100-51-6 benzyl alcohol 
• 3587-60-8 Benzyloxymethyl chloride 
• 127-08-2 potassium acetate 
• 625-56-9 Chloromethyl acetate 
• 64-19-7 acetic acid 
• 88738-41-4 <<(methoxyethoxy)methoxy>methyl>benzene 
• 5658-46-8 ((2-methylallyloxy)methyl)benzene 

Downstream Products

• 14548-60-8 phenylmethoxymethanol 
• 160234-23-1 1-(benzyloxymethyl)-cyclopentanopyrimidine-2,4-dione 
• 160234-24-2 1-(benzyloxymethyl)-1,2,3,4,5,6,7,8-octahydroquinazoline-2,4-dione 
• 190835-45-1 3-Benzyl-1-benzyloxymethyl-2,2-dioxo-2,3-dihydro-1H-2λ⁶-benzo[1,2,6]thiadiazin-4-one 
• 221632-89-9 3-Benzyloxymethyl-2,2-dioxo-2,3-dihydro-1H-2λ⁶-benzo[1,2,6]thiadiazin-4-one 
• 1154032-30-0 1-(benzyloxymethyl)-5-bromo-6-(2,4-dichlorophenoxymethyl)uracil 
• 1154032-28-6 1-(benzyloxymethyl)-6-(2,4-dichlorophenoxymethyl)-5-iodouracil 
• 1154032-29-7 1-(benzyloxymethyl)-5-chloro-6-(2,4-dichlorophenoxymethyl)uracil 

Relevant academic research and scientific papers

Acid catalyzed rearrangement of vinyl and ketene acetals

Substituted vinyl and ketene acetals undergo smooth oxygen-to-carbon rearrangement with a catalytic amount of TMSOTf to afford chain-extended ketones or esters, respectively. The developed procedure has been applied to the stereoselective synthesis of C-glycosides from the corresponding anomeric vinyl ethers.

Iron(III) triflate-catalyzed one-pot synthesis of acetal-type protected cyanohydrins from carbonyl compounds

A variety of cyanohydrin THP ethers were readily prepared from carbonyl compounds with trimethylsilyl cyanide and tetrahydropyran-2-yl acetate under the influence of a catalytic amount of iron(III) triflate in a convenient one-pot procedure. This method was also effective to prepare O-protected cyanohydrins by various acetal-type protective groups.

Cleavage of 2-methoxyethoxymethyl ethers catalyzed by cerium(IV) ammonium nitrate (CAN) in acetic anhydride

The reactions of 2-methoxyethoxymethyl (MEM) ethers 1 with a catalytic amount of cerium(IV) ammonium nitrate (CAN) in acetic anhydride gave the corresponding mixed acetal esters 2 and acetates 3.

Syntheses of α,β-unsaturated carbonyl compounds from the reactions of monosubstituted ozonides with stable phosphonium ylides

Ozonides derived from terminal alkenes reacted with 1.3 mol equiv. of stable phosphonium ylides to give (E)-αβ-unsaturated carbonyl compounds in good to excellent yields. No reducing agent is needed in the reaction. However, alkoxyalkyl-substituted ozonides afforded a mixture of (Z)- and (E)-αβ-unsaturated carbonyl compounds under similar condition. The E/Z isomeric ratio is affected by the position of the heteroatom in the substituent of the ozonides. The possible mechanism of this reaction will be discussed. (C) 2000 Elsevier Science Ltd.

Synthesis of acyclic thieno[3,2-d]pyrimidine nucleosides and azido derivatives as potential anti-HIV agents

A series of thieno[3,2-d]pyrimidine-2,4-diones alkylated with acyclic chains have been synthesized related to the antiherpetic agents (acyclovir and ganciclovir) and to EBPU which was reported to display in vitro antiviral activity against human immunodeficiency virus type 1 (HIV-1). Conversion of the hydroxy-acyclic nucleosides into their azido derivatives was then examined using triphenylphosphine - carbon tetraiodide - sodium azide. All the compounds, however, did not exhibit any significant inhibitory activity against HIV-1 in CEM cl 13 cells.

Synthesis and antiviral study of cyclopentano [d] pyrimidine-2,4-diones and octahydroquinazoline-2,4-diones acyclic nucleosides as potential anti- HIV agents

The Vorbruggen and Niedballa's method afforded new cyclopentano [d] pyrimidine-2,4-dione and octahydroquinazoline-2,4-dione nucleosides. Various modifications of these new derivatives enabled us to obtain HEPT related compounds which were tested against H

Synthesis and antiviral study of dihydrothieno and thianopyrimidine diones acyclic nucleosides as potential anti-HIV agents

Acyclic nucleosides were prepared by alkylation of dihydrothieno and thianopyrimidines diones following Vorbruggen and Niedballa's method. None of these HEPT analogues showed significant activity against Human Immunodeficiency Virus-1 (HIV-1).

Synthesis of thieno[3,2-d]pyrimidine-2,4-diones cyclic and acyclic nucleosides as potential anti HIV agents

Synthesis of cyclic and acyclic nucleosides was achieved by alkylation of 7-methyl or arylthieno[3,2-d]pyrimidine-2,4-diones following the Vorbruggen and Niedballa's method [1]. After a possible deprotection, potential anti HIV agents were obtained.