1909-25-7

Usage

Uses

Used in Pharmaceutical Industry:
N-(p-Methylphenacyl)-phthaliMide is used as an intermediate for the synthesis of aryloxoalkyl phthalimides, which are known for their antiproliferative properties. These properties are crucial in the development of pharmaceuticals that target the proliferation of cancer cells, making it a vital component in the fight against various types of cancer.
Used in Research and Development:
In addition to its application in the pharmaceutical industry, N-(p-Methylphenacyl)-phthaliMide is also utilized in research and development for the study of antiproliferative agents. Its role as an intermediate allows scientists to explore and develop new compounds with potential applications in cancer treatment and other related fields.
Used in Drug Delivery Systems:
Similar to gallotannin, N-(p-Methylphenacyl)-phthaliMide could potentially be incorporated into drug delivery systems to enhance the bioavailability and therapeutic outcomes of the resulting pharmaceuticals. By employing various organic and metallic nanoparticles as carriers, the compound's delivery and efficacy against cancer cells could be improved, leading to more effective treatments.

Upstream product

• 6780-38-7 N-phthaloylglycine chloride 
• 108-88-3 toluene 
• 1074-82-4 potassium phtalimide 
• 4209-24-9 p-methylphenacyl chloride 
• 619-41-0 4-(bromoacetyl)toluene 
• 136918-14-4 phthalimide 
• 104-87-0 4-methyl-benzaldehyde 
• 861018-73-7 2-(4-methylphenethyl)isoindoline-1,3-dione 
• 3261-62-9 2-(p-tolyl)ethylamine 
• 7559-36-6 4-methyl-β-nitrostyrene 

Downstream Products

• 1071964-64-1 1-(1-tert-butyl-3-p-tolyl-1H-pyrazol-4-yl)-3-(5-(2-morpholinoethoxy)-2H-chromen-8-yl)urea 
• 1071964-77-6 1-tert-butyl-3-(p-tolyl)-4-phthalimido-pyrazole 
• 1071964-78-7 1-tert-butyl-3-(p-tolyl)-4-amine-1H-pyrazole 
• 1071964-76-5 N,N-dimethyl-3-(isoindoline-1,3-dione-2yl)-2-p-tolylprop-1-en-1-amine 
• 120450-05-7 2-amino-4-p-tolyl-1H-pyrrole-3-carbonitrile 

Relevant academic research and scientific papers

Combined Photoredox/Enzymatic C?H Benzylic Hydroxylations

Chemical transformations that install heteroatoms into C?H bonds are of significant interest because they streamline the construction of value-added small molecules. Direct C?H oxyfunctionalization, or the one step conversion of a C?H bond to a C?O bond, could be a highly enabling transformation due to the prevalence of the resulting enantioenriched alcohols in pharmaceuticals and natural products,. Here we report a single-flask photoredox/enzymatic process for direct C?H hydroxylation that proceeds with broad reactivity, chemoselectivity and enantioselectivity. This unified strategy advances general photoredox and enzymatic catalysis synergy and enables chemoenzymatic processes for powerful and selective oxidative transformations.

Synthesis and Biological Evaluation of Chromenylurea and Chromanylurea Derivatives as Anti-TNF-a agents that Target the p38 MAPK Pathway

A series of 1-aryl-3-(2H-chromen-5-yl)urea and 1-aryl-3-(chroman-5-yl)urea derivatives were designed, synthesized and evaluated for their inhibitory activities towards TNF-a production in lipopolysaccharide-stimulated THP-1 cells. The most active compound, 40g, inhibited TNF-a release with an IC50 value of 0.033 μM, which is equipotent to that of BIRB796 (IC50 = 0.032 μM).

Efficient preparation of biologically important 1,2-amino alcohols

An efficient three-step methodology developed for the preparation of 1,2-amino alcohols. In the first step a rapid coupling between bromoketones and potassium phthalimide in ionic liquid produced-phthalimido ketones in quantitative yields, which is followed by a facile reduction using NaCNBH 3 in acetic acid to give corresponding phthalimido alcohols and finally effecting hydrazinolysis in water at 60C to yield biologically important 1,2-amino alcohols.

KINASE INHIBITORS

Methods of inhibiting kinases using kinase inhibitors having olefin moieties are disclosed.

The preparation and in vitro antiproliferative activity of phthalimide based ketones on MDAMB-231 and SKHep-1 human carcinoma cell lines

The 'one pot' condensation reaction for the synthesis and potent antiproliferative inhibition of α-phthalimide based ketones is reported here. 2-Phthalimide-1-(4-fluoro-phenyl)ethanone (5) showed the best growth inhibition on human MDAMB-231 breast carcin

Palladium-catalyzed asymmetric hydrogenation of functionalized ketones

(Chemical Equation Presented) A novel catalytic system for asymmetric hydrogenation of functionalized ketones has been developed using a Pd/bisphosphine complex as the catalyst in 2,2,2-trifluoroethanol. The reaction exhibits high enantioselectivity, and

Ru-catalyzed asymmetric hydrogenation of α-phthalimide ketones and 1,3-diaryl diketones using 4,4′-substituted BINAPs

(Chemical Equation Presented) A family of tunable precatalysts [NH 2Et2][{Ru(4,4′-BINAP)Cl}2(μ-Cl) 3] was synthesized and used for highly enantioselective hydrogenation of phthalimide-protected amino ketones and

Highly Enantioselective Asymmetric Hydrogenation of α-Phthalimide Ketone: An Efficient Entry to Enantiomerically Pure Amino Alcohols

A new type of α-phthalimide ketones was hydrogenated in excellent enantioselectivity by using a Ru-(C3-TunePhos) complex as the catalyst. Up to 10000 turnovers have been achieved in more than 99% ee in the hydrogenation reaction. A dynamic kinetic resolution study for the synthesis of threonine was performed, and high anti selectivity (>97:3) was observed for the first time. An efficient method to synthesize enantiomerically pure amino alcohols has been developed. Copyright

New Anticancer Agents: Synthesis of 1,2-Dihydropyridopyrizines (1-Deaza-7,8-dihydropteridines)

Reaction of α-aminoacetophenone oximes (2) with ethyl 6-amino-4-chloro-5-nitropyridine-2-carbamate (1) gave ethyl 6-amino-5-nitro-4-pyridine-2-carbamate oximes (3), which were hydrolyzed under acidic conditions to give the corresponding ketones (4).Related pyridines substituted with keto side chain were prepared from 1 and 1,3-diaminopropanone oximes and by oxidation of the side-chain hydroxy group of ethyl 6-amino-4-amino>-5-nitropyridine-7-carbamates (6).Catalytic hydrogenation of the nitro group of 4 over Raney nickel in a large volume of ethanol gave the 1-deaza-7,8-dihydropteridines (7).Several of the oximes 3 were successfully hydrogenated to give 7 directly.The resulting 1-deaza-7,8-dihydropteridines showed potent cytotoxicity against cultured L1210 cells and significant anticancer activity against lymphocytic leukemia P-388 in mice.THese biological activities are attributed to the accumulation of cells at mitosis.