190954-07-5Relevant academic research and scientific papers
Practical synthesis of DQ-113, a new quinolone antibacterial agent, by using the intramolecular Horner-Wadsworth-Emmons reaction
Inagaki, Hiroaki,Takeda, Toshiyaki,Miyauchi, Rie N.,Kawakami, Katsuhiro,Takahashi, Hisashi,Takemura, Makoto
, p. 699 - 706 (2007/10/03)
A practical route was developed for synthesizing the C-7 substituent of DQ-113 (6, 5-amino-7-[(3S,4R)-4-(1-aminocycloprop-1-yl)-3-fluoropyrrolidin-1-yl] -6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-1, 4-dihydro-8-methyl-4-oxoquinolin-3-carboxylic acid),
Synthesis and structure - Activity relationships of 5-amino-6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-8- methylquinolonecarboxylic acid antibacterials having fluorinated 7-[(3R)-3-(1-aminocyclopropan-1-yl)pyrrolidin-1-yl] substituents
Inagaki, Hiroaki,Miyauchi, Satoru,Miyauchi, Rie N.,Kawato, Haruko C.,Ohki, Hitoshi,Matsuhashi, Norikazu,Kawakami, Katsuhiro,Takahashi, Hisashi,Takemura, Makoto
, p. 1005 - 1015 (2007/10/03)
A series of novel 5-amino-6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-8-methylquinolones bearing fluorinated (3R)-3-(1-aminocyclopropan-1-yl)pyrrolidin-1-yl substituents at the C-7 position (2-4) was synthesized to obtain potent drugs for infections cau
