19100-10-8

Upstream product

• 46147-85-7 1-pyridin-3-yl-cyclohexanol 
• 2044-08-8 1-bromocyclohex-1-ene 
• 89878-14-8 3-Diethylboranylpyridine 
• 28075-50-5 cyclohex-1-en-1-yl trifluoromethane sulfonate 
• 1692-25-7 3-pyridylboronic acid 
• 626-55-1 3-Bromopyridine 
• 4545-18-0 N'-cyclohexylidene-4-methylbenzene-1-sulfonohydrazide 
• 141091-37-4 2-(cyclohex-1-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 110-83-8 cyclohexene 
• 108-94-1 cyclohexanone 

Downstream Products

• 16219-90-2 3-cyclohexylpyridine 
• 1225224-58-7 8-chloro-5-(2-(3-pyridyl)cyclohex-1-yl)-2,3,4,5-tetrahydro-2-methyl-1H-pyrido[4,3-b]indole 

Relevant academic research and scientific papers

Expedient synthesis of gem-dialkylbenzyl heterocycles through olefinic hydroarylation

A robust approach to gem-dialkylbenzyl heterocycles has been developed through a triflic acid-catalyzed hydroarylation of olefinic heterocycles. A broad range of substrates containing pyridine, quinoline, pyrazole, triazole and imidazole moieties are shown to be highly compatible with this method. This rapid construction of gem-dialkyl groups should be useful in the synthesis of drug-like molecules containing heterocyclic diversity and in the study of the gem-dialkyl effect.

Cycloalkane Derivatives

Disclosed herein are therapeutic agents and/or preventive agents for pain or therapeutic agents and/or preventive agents for a sodium channel associated disease. The present invention provides compounds represented by the following formula (I) or pharmacologically acceptable salts thereof:

Selective arylation at the vinylic site of cyclic olefins

Cyclic olefins usually give Heck products having an aryl ring residing at the allylic or homoallylic position. We describe herein a new method that allows arylation at the vinylic position of various cyclic olefins.

Palladium catalyzed coupling of tosylhydrazones with aryl and heteroaryl halides in the absence of external ligands: Synthesis of substituted olefins

Palladium catalyzed cross-coupling reaction of hydrazones with aryl halides in the absence of external ligand is reported. The versatility of this coupling reaction is demonstrated in showcasing the selectivity of coupling reaction in the presence of hydr

PYRIDO (4,3-B) INDOLES CONTAINING RIGID MOIETIES

This disclosure is directed to pyrido[4,3-b]indoles having rigid moieties. The compounds in one embodiment are pyrido[4,3-b]indoles having an unsaturated hydrocarbon moiety. The compounds in another embodiment are pyrido[4,3-b]indoles having a cycloalkyl, cycloalkenyl or heterocyclyl moiety. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.

COMPOUNDS WITH ACTIVITY AT ESTROGEN RECEPTORS

Disclosed herein are methods of treating neuropathic pain, reducing inflammation, reducing IL-4 levels, and reducing IFN-γ levels, using various di-aromatic compounds for use as estrogen receptors β agonists.

A NOVEL SYNTHESIS OF 3- AND 4-ALKENYLPYRIDINES

A new approach for the simple preparation of 3- and 4-alkenylpyridines that relys upon the palladium catalyzed cross coupling reaction of diethylpyridylboranes with vinylic bromides is described.