191014-55-8

Basic information

• Product Name: 4-Fluoro-2-methoxybenzonitrile
• Synonyms: 4-FLUORO-2-METHOXYBENZONITRILE;BUTTPARK 80\07-22;Benzonitrile, 4-fluoro-2-methoxy- (9CI);4-Fluoro-o-anisonitrile, 2-Cyano-5-fluoroanisole
• CAS NO: 191014-55-8
• Molecular Formula: C₈H₆FNO
• Molecular Weight: 151.14
• Product Categories: HALIDE;Aromatic Nitriles;Anisoles, Alkyloxy Compounds & Phenylacetates;Fluorine Compounds;Nitriles;Fluorine series
• Mol File: 191014-55-8.mol
• Article Data: 11

Chemical Properties

• Melting Point: 75 °C
• Boiling Point: 239.2 °C at 760 mmHg
• Flash Point: 98.5 °C
• Appearance: /
• Density: 1.18 g/cm³
• Vapor Pressure: 0.0405mmHg at 25°C
• Refractive Index: 1.505
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-Fluoro-2-methoxybenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluoro-2-methoxybenzonitrile(191014-55-8)
• EPA Substance Registry System: 4-Fluoro-2-methoxybenzonitrile(191014-55-8)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 23-36/37/39
• RIDADR: 3276
• HazardClass: 6.1
• Hazardous Substances Data: 191014-55-8(Hazardous Substances Data)

Usage

Chemical Properties

off-white crytalline

InChI:InChI=1/C8H6FNO/c1-11-8-4-7(9)3-2-6(8)5-10/h2-4H,1H3

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 456-49-5 1-fluoro-3-methoxybenzene 
• 748101-41-9 zinc cyanide 
• 450-88-4 1-bromo-4-fluoro-2-methoxybenzene 
• 147460-41-1 2-bromo-5-fluorophenol 
• 557-21-1 zinc(II) cyanide 
• 3939-09-1 2,4-difluorobenzonitrile 
• 865-33-8 potassium methanolate 
• 544-92-3 copper(I) cyanide 

Downstream Products

• 1173006-40-0 2-methoxy-4-(propan-2-yloxy)benzonitrile 
• 914102-52-6 4-(4,4-dimethyl-2-oxo-tetrahydro-furan-3-yloxy)-2-methoxy-benzonitrile 
• 1379366-31-0 5-bromo-4-fluoro-2-methoxybenzonitrile 
• 870563-60-3 (4-fluoro-2-methoxyphenyl)methanamine 
• 1213591-14-0 (S)-4-((4-bromo-2,3-dihydro-1H-inden-1-yl)amino)-2-methoxybenzonitrile 
• 1435949-41-9 2-methoxy-4-(3-methylphenoxy)benzoic acid 
• 1435949-43-1 2-hydroxy-4-(3-methylphenoxy)benzoic acid 
• 1436378-70-9 2-hydroxy-N-[(1S)-1-{[(3S)-4-(3-hydroxyphenyl)-3-methylpiperazin-1-yl]methyl}-2-methylpropyl]-4-(3-methylphenoxy)benzamide 
• 1436378-69-6 N-[(1S)-1-{[(3S)-4-(3-hydroxyphenyl)-3-methylpiperazin-1-yl]-methyl}-2-methylpropyl]-2-methoxy-4-(3-methylphenoxy)benzamide 

Relevant articles and documents

Direct C-H Cyanation of Arenes via Organic Photoredox Catalysis

Methods for the direct C-H functionalization of aromatic compounds are in demand for a variety of applications, including the synthesis of agrochemicals, pharmaceuticals, and materials. Herein, we disclose the construction of aromatic nitriles via direct C-H functionalization using an acridinium photoredox catalyst and trimethylsilyl cyanide under an aerobic atmosphere. The reaction proceeds at room temperature under mild conditions and has proven to be compatible with a variety of electron-donating and -withdrawing groups, halogens, and nitrogen- and oxygen-containing heterocycles, as well as aromatic-containing pharmaceutical agents.

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula Ia and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.

CYCLIC AMINE COMPOUND

A compound represented by the formula (I) or a salt thereof: (I) wherein the ring A represents a 5- to 8-membered ring which may have additional substituent besides R6, R7 and R8; R1 represents an electron-attracting group; R2, R3, R4 and R5 independently represent a hydrogen atom, a halogen atom, a group attached through a carbon atom, a group attached through a nitrogen atom, a group attached through an oxygen group, or a group attached through a sulfur atom; R6 represents a halogen atom, a group attached through a carbon atom, a group attached through a nitrogen atom, a group attached through an oxygen group, or a group attached through a sulfur atom, and R7 represents a cyano group, a nitro group, an acyl group which may have a substituent, a carboxyl group which may be esterified or amidated, or a hydrocarbon group which may have a substituent, or R6 and R7 together with a carbon atom to which they are attached may form a ring which may have a substituent; and R8 represents a hydrogen atom, a halogen atom, a group attached through a carbon atom, a group attached through an oxygen atom, or a group attached through a sulfur atom. The compound or salt has an excellent androgen receptor modulating effect, and is useful for the prevention/treatment of hypogonadism, partial androgen deficiency in aging male, decline in physical strength, cachexia, osteoporosis and the like.