1910803-72-3

Basic information

• Product Name: Biotin-PEG2-azide
• Synonyms: Biotin-PEG2-azide
• CAS NO: 1910803-72-3
• Molecular Formula: C16H29N6O4S+
• Molecular Weight: 401.50426
• Mol File: 1910803-72-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Biotin-PEG2-azide(CAS DataBase Reference)
• NIST Chemistry Reference: Biotin-PEG2-azide(1910803-72-3)
• EPA Substance Registry System: Biotin-PEG2-azide(1910803-72-3)

Safety Data

• Hazardous Substances Data: 1910803-72-3(Hazardous Substances Data)

Usage

General Description

Biotin-PEG2-azide is a chemical compound that consists of a biotin molecule attached to a polyethylene glycol (PEG) spacer, which is in turn linked to an azide group. The biotin molecule allows for specific binding to streptavidin or avidin proteins, making it useful for various biological applications such as protein detection and purification. The PEG spacer provides flexibility and solubility, while the azide group is commonly used for bioconjugation reactions involving click chemistry. Biotin-PEG2-azide is often employed in bioconjugation and labeling processes, as well as in the development of diagnostic tools and bioassays in biological and medical research.

Upstream product

• 166388-57-4 2-[2-(2-azidoethoxy)ethoxy]ethanamine 
• 59559-06-7 1,8-diazido-3,6-dioxaoctane 
• 58-85-5 biotin 
• 929537-66-6 C₂HF₃O₂*C₆H₁₄N₄O₂ 

Relevant articles and documents

The Synthesis and Biological Evaluation of Some C-9 and C-10 Substituted Derivatives of the RNA Polymerase i Transcription Inhibitor CX-5461

The regio-isomeric alkynyl-substituted derivatives, 2 and 3, of the RNA Polymerase I (Pol I) transcription inhibitor CX-5461 (1) were prepared and the active one (compound 3) subjected to click reactions ([3 + 2]-cycloaddition reactions) with certain alkyl azides bearing biotin or fluorescent tags. Compounds 2 and 3, as well as four [3 + 2]-cycloadducts of the latter, were subjected to biological evaluation in a human acute myeloid leukemia cell line model. Among the six compounds tested only alkyne 3 remained active but this was less potent than parent 1.

Rational design of biotin-disulfide-coumarin conjugates: A cancer targeted thiol probe and bioimaging

Biotin-disulfide-coumarin conjugates are designed and synthesized as novel fluorescent sensors for cancer targeted intracellular thiol imaging in living organisms. In vitro experiments disclose that probe 6 is preferentially taken up by biotin receptor-positive A549 tumor cells through receptor mediated endocytosis. The Royal Society of Chemistry.

Design, synthesis, and biological evaluation of biotin-labeled (-)-ternatin, a potent fat-accumulation inhibitor against 3T3-L1 adipocytes

The design, synthesis, and biological activity of biotin-labeled (-)-ternatin are reported. Chemical modification, that is, biotinylation, was conducted using Click chemistry at the 6-position (NMe-d-ProGly moiety), which was a plausible location selected