191089-78-8

Basic information

• Product Name: 3-((4-FLUOROPHENYL)AMINO)CYCLOHEX-2-EN-1-ONE
• Synonyms: 3-((4-FLUOROPHENYL)AMINO)CYCLOHEX-2-EN-1-ONE;2-cyclohexen-1-one, 3-[(4-fluorophenyl)amino]-;3-((4-fluorophenyl)amino)cyclohex-2-enone;3-[(4-fluorophenyl)amino]-1-cyclohex-2-enone;3-(4-fluoroanilino)cyclohex-2-en-1-one
• CAS NO: 191089-78-8
• Molecular Formula: C₁₂H₁₂FNO
• Molecular Weight: 205.23
• Mol File: 191089-78-8.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-((4-FLUOROPHENYL)AMINO)CYCLOHEX-2-EN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-((4-FLUOROPHENYL)AMINO)CYCLOHEX-2-EN-1-ONE(191089-78-8)
• EPA Substance Registry System: 3-((4-FLUOROPHENYL)AMINO)CYCLOHEX-2-EN-1-ONE(191089-78-8)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 191089-78-8(Hazardous Substances Data)

Upstream product

• 504-02-9 1,3-cylohexanedione 
• 371-40-4 4-fluoroaniline 
• 765-87-7 cyclohexane-1,2-dione 

Downstream Products

• 1276542-93-8 2-amino-1-(4-fluorophenyl)-4-(3-(4-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1276542-86-9 2-amino-4-(1,3-diphenyl-1H-pyrazol-4-yl)-1-(4-fluorophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1276542-94-9 2-amino-1-(4-fluorophenyl)-5-oxo-4-(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1276542-91-6 2-amino-1-(4-fluorophenyl)-5-oxo-4-(1-phenyl-3-p-tolyl-1H-pyrazol-4-yl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1276542-89-2 2-amino-1-(4-fluorophenyl)-4-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1276542-88-1 2-amino-4-(3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl)-1-(4-fluorophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1276542-87-0 2-amino-4-(3-(4-bromophenyl)-1-phenyl-1H-pyrazol-4-yl)-1-(4-fluorophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1276542-90-5 2-amino-1-(4-fluorophenyl)-4-(3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 88368-12-1 6-fluoro-1,2,3,9-tetrahydro-4H-carbazol-4-one 
• 1628708-19-9 2-cyano-2-[1-(4-fluorophenyl)-4-oxo-2-phenyl-4,5,6,7-tetrahydro-1H-3-indolyl]acetamide 
• 1421844-67-8 1-(4-fluorophenyl)-6,7-dihydro-3-(1H-indol-2-yl)-2-phenyl-1H-indol-4(5H)-one 
• 1401913-00-5 5-(4-fluorophenyl)-5,10-dihydro-10-oxoindeno[1,2-b]indol-9-yl propionate 
• 1401912-92-2 5-(4-fluorophenyl)-5,10-dihydro-10-oxoindeno[1,2-b]indol-9-yl acetate 
• 1422451-30-6 10-(4-fluorophenyl)-9-(7-methoxytetrazolo[1,5-a]-quinolin-4-yl)-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione 

Relevant articles and documents

Hypervalent Iodine(III)-Mediated Counteranion Controlled Intramolecular Annulation of Exocyclic β-Enaminone to Carbazolone and Imidazo[1,2-a]pyridine Synthesis

A highly efficient and flexible protocol for intramolecular annulation of exocyclic β-enaminones has been disclosed for the synthesis of carbazolones and imidazo[1,2-a]pyridines through a counter-anion-controlled free-radical mechanism promoted by hypervalent iodine(III). The cooperative behavior of HTIB and AgSbF6 plays a crucial role in the intramolecular annulation process through C?C and C?N bond formation to give the desired products. The mechanistic insights suggest that the two competitive reactions involved in the system are guided by the nature of the counteranion, which determines the formation of the final products. A wide variety of carbazolones and imidazo[1,2-a]pyridine molecules have been prepared and isolated in good to excellent yields.

Iodine(III)-Promoted Ring Contractive Cyanation of Exocyclic β-Enaminones for the Synthesis of Cyanocyclopentanones

A highly efficient hypervalent iodine-promoted regiocontrolled ring contractive cyanation (RCC) reaction of exocyclic β-enaminones for the synthesis of cyanocyclopentanone (CCP) was demonstrated at ambient temperature with a wide substrate scope. The meth

Synthesis and antimicrobial activity of some new N-substituted quinoline derivatives of 1H-pyrazole

A new series of 32 derivatives of 4-pyrazolyl-N-(hetero)arylquinoline 5a-p and 6a-p were synthesized by a one-pot base-catalyzed cyclocondensation reaction of 1-phenyl-3-(hetero)aryl-pyrazole-4-carbaldehyde 1a-h, malononitrile 2, and 3-(hetero)aryl-5,5-disubstitutedcyclohex-2-enone 3a-b or 4a-b, respectively. All the synthesized compounds were characterized by elemental analysis, FT-IR, 1H-NMR, and 13C-NMR spectral data. All the synthesized compounds were screened, against six bacterial pathogens, namely Bacillus subtilis, Clostridium tetani, Streptococcus pneumoniae, Salmonella typhi, Vibrio cholerae, Escherichia coli, and antifungal activity, against two fungal pathogens Aspergillus fumigatus and Candida albicans, using broth microdilution MIC method. Some of the compounds were found to be more or equipotent against most of the employed strains than commercially available drugs as evident from the screening data. Quinoline derivatives are known to exhibit a wide range of biological activities. Therefore, a series of some new 1,4-di(hetero)aryl quinoline derivatives bearing a 1H-pyrazole nucleus have been synthesized and were evaluated for their antimicrobial activities against a panel of human pathogens. Copyright