191105-72-3Relevant academic research and scientific papers
A modular rearrangement approach toward medicinally relevant phosphinic structures
Rogakos, Vassilis,Georgiadis, Dimitris,Dive, Vincent,Yiotakis, Athanaslos
supporting information; experimental part, p. 4696 - 4699 (2009/12/08)
An unprecedented coupling of a P - C and a C - C bond-forming event In a practical operation was developed to access medicinally relevant phosphinic structures. The strategy relies on an Ireland-Claisen rearrangement triggered by the phospha-Michael addition of silyl phosphonltes to allyl acrylates. This protocol was extended to a more versatile three-component variant that utilizes phosphinic acids, acryloyl chlorides, and allylic alcohols as starting materials.
