191109-44-1

Basic information

• Product Name: (R)-4-(p-chlorophenyl)-1,3-dioxolane-2-one
• Synonyms: (R)-4-(p-chlorophenyl)-1,3-dioxolane-2-one
• CAS NO: 191109-44-1
• Molecular Weight: 198.606
• Mol File: 191109-44-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-4-(p-chlorophenyl)-1,3-dioxolane-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-(p-chlorophenyl)-1,3-dioxolane-2-one(191109-44-1)
• EPA Substance Registry System: (R)-4-(p-chlorophenyl)-1,3-dioxolane-2-one(191109-44-1)

Safety Data

• Hazardous Substances Data: 191109-44-1(Hazardous Substances Data)

Upstream product

• 124-38-9 carbon dioxide 
• 2788-86-5 4-Chlorostyrene oxide 
• 204581-98-6 (R)-4-(4-Chloro-phenyl)-[1,3,2]dioxathiolane 2-oxide 
• 108-59-8 malonic acid dimethyl ester 
• 152142-03-5 (1R)-1-(4-chlorophenyl)-1,2-ethanediol 
• 616-38-6 carbonic acid dimethyl ester 

Downstream Products

• 191109-58-7 2-(Bis-{[(S)-1-(4-chloro-phenyl)-2-hydroxy-ethylcarbamoyl]-methyl}-amino)-N-[(S)-1-(4-chloro-phenyl)-2-hydroxy-ethyl]-acetamide 
• 191109-51-0 (S)-1-(4-chlorophenyl)-2-hydroxyethylamine 
• 169272-17-7 (S)-2-azido-2-(4-chlorophenyl)ethanol 

Relevant articles and documents

Chiral Macrocyclic Organocatalysts for Kinetic Resolution of Disubstituted Epoxides with Carbon Dioxide

Among chiral macrocycles 1 synthesized, 1m with the 3,5-bis(trifluoromethyl)phenylethynyl group was the best organocatalyst for the enantioselective synthesis of cyclic carbonates from disubstituted or monosubstituted epoxides and CO2. The X-ray crystal structure of 1m revealed a well-defined chiral cavity with multiple hydrogen-bonding sites that is suitable for the enantioselective activation of epoxides. A catalytic cycle proposed was supported by DFT calculations.

Enantioselective allylic oxidation of cycloalkenes by using Cu(II)-tris(oxazoline) complex as a catalyst

Optically active copper(II)-tris(oxazoline) complex that was synthesized as a model compound of the active site of non-heme oxygenase, was found to catalyze allylic oxidation of cycloalkenes to give the corresponding 2-cycloalkenyl benzoates with moderate to excellent enantioselectivity (up to 93% ee) under die Kharash-Sosnovsky reaction conditions.