19111-35-4

Upstream product

• 19111-32-1 4-Hydroxy-3-phenyl-4H-1,4-benzothiazin-1,1-dioxid 
• 4875-10-9 o-nitrothiophenol 
• 20940-09-4 2-(2-nitro-phenylsulfanyl)-1-phenyl-ethanone 
• 70-11-1 α-bromoacetophenone 
• 1078587-21-9 tert-butyl 2-[(2-oxo-2-phenylethyl)sulfonyl]phenyl-carbamate 
• 2557-78-0 2-fluorothiophenol 
• 61081-27-4 2-((2-fluorophenyl)thio)acetonitrile 
• 1384585-68-5 C₁₄H₁₂FNO₂S 
• 98-88-4 benzoyl chloride 
• 2987-53-3 2-(Methylthio)aniline 
• 76148-78-2 2-((2-nitrophenyl)sulfonyl)-1-phenylethan-1-one 
• 73153-48-7 2-benzoylaminophenyl methyl sulphone 

Downstream Products

• 19415-30-6 2-morpholin-4-ylmethyl-3-phenyl-4H-benzo[1,4]thiazine 1,1-dioxide 
• 19415-26-0 1,1-dioxo-3-phenyl-1,4-dihydro-1λ⁶-benzo[1,4]thiazine-2-carbaldehyde 
• 19415-32-8 2-nitro-3-phenyl-4H-benzo[1,4]thiazine 1,1-dioxide 
• 19415-34-0 1,1-dioxo-3-phenyl-1,4-dihydro-1λ⁶-benzo[1,4]thiazin-2-ylamine 

Relevant academic research and scientific papers

Use of (Z)-β-(2-fluorobenzenesulfonyl)vinylamines as novel synthons in the synthesis of 1,4-benzothiazine derivatives

A novel synthetic route for arylated 1,4-benzothiazine derivatives has been developed. This method utilizes a key intramolecular nucleophilic aromatic substitution step of the corresponding (Z) - (2-fluorobenzenesulfonyl)vinylamine intermediate to construct the benzothiazine ring. A wide range of aryl and heteroaryl substituent groups can be installed from commercial boronic acids. Both mono- and diarylated products have been synthesized in good yields and with good functional group tolerance. Georg Thieme Verlag Stuttgart · New York.

High yield synthesis of 4H-1,4-benzothiazine-1,1-dioxide derivatives

(Chemical Equation Presented) 4H-1,4-Benzothiazine-1,1-dioxide derivatives were synthesized through a sequence of almost quantitative reactions. The commercial starting material 2-(methylsulfanyl)aniline was Boc-protected, N-acylated and oxidized at the sulfur atom to obtain a sulfonyl derivative. An anionic transposition of the acyl group followed by a simultaneous deprotection-cyclization gave the title products in excellent yields. All products and intermediates were fully characterized.

From phenothiazine to 3-phenyl-1,4-benzothiazine derivatives as inhibitors of the Staphylococcus aureus NorA multidrug efflux pump

Overexpression of efflux pumps is an important mechanism by which bacteria evade effects of substrate antimicrobial agents and inhibition of such pumps is a promising strategy to circumvent this resistance mechanism. NorA is a Staphylococcus aureus multid

Ortho Effects in Organic Molecules on Electron Impact. Part 22. Competing Oxygen Transfers from the Nitro Group to Sulphur and the Olefinic Double Bond in 2-Nitrophenyl Styryl Sulphides

Double oxygen migration to sulphur from the ortho-nitro group leading to eliminations of SO2 and SO2H from the molecular ions and single oxygen transfer to the olefinic double bond in the side-chain giving rise to the most abundant ion at m/z 138 have bee

Synthesis of 4H-1,4-Benzothiazines via Lithiation Alpha to Sulphur of 2-Acylaminophenyl Alkyl Sulphides, Sulphoxides, and Sulphones

4H-1,4-Benzothiazines, their monoxides, and their dioxides are readily prepared via lithiation and intramolecular cyclisation of 2-acylaminophenyl alkyl sulphides, sulphoxides, and sulphones with lithium di-isopropylamide in tetrahydrofuran at -50 deg C.

New dyes based on 3-aryl-benzo- and -naphtho-1,4-thiazines

3-Aryl-2H-1,4-benzothiazines have been converted into cyanine dyes by condensing their hydroperchlorates with aldehydes, and into azo-compounds by coupling with reactive diazonium salts. The azo-compounds were also obtained by condensing arylglyoxal hydra