191152-31-5

Upstream product

• 102717-29-3 (5S)-5-({[tert-butyl(diphenyl)silyl]oxy}methyl)dihydrofuran-2(3H)-one 
• 67-64-1 acetone 
• 78508-96-0 (5S)-5-(hydroxymethyl)-5H-furan-2-one 
• 99315-76-1 (5S)-5-(tert-butyldiphenylsiloxymethyl)-2(5H)-furanone 
• 91926-90-8 ethyl (Z)-3-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)acrylate 
• 4039-32-1 lithium hexamethyldisilazane 

Downstream Products

• 191152-32-6 Oxalic acid 1-[(3S,5S)-5-(tert-butyl-diphenyl-silanyloxymethyl)-2-oxo-tetrahydro-furan-3-yl]-1-methyl-ethyl ester methyl ester 
• 191152-26-8 (3S,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-isopropyl-dihydro-furan-2-one 
• 191152-27-9 (3S,5S)-5-Hydroxymethyl-3-isopropyl-dihydro-furan-2-one 
• 325740-73-6 (3R,5S)-5-Hydroxymethyl-3-isopropyl-dihydro-furan-2-one 
• 191152-33-7 (S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-isopropylidene-dihydro-furan-2-one 

Relevant academic research and scientific papers

NOVEL SUBSTITUTED AMINOTHIAZOLOPYRIMIDINEDIONE FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION

The present invention relates to compounds of formula (I), wherein R1 to R5 are as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

NOVEL 3-SUBSTITUTED 5-AMINO-6H-THIAZOLO[4,5-D]PYRIMIDINE-2,7-DIONE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION

The present invention relates to compounds of formula (I), wherein R1, R2 and R3 are as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

Synthesis of (4S)-hydroxymethyl-(2R)-(2-propyl)-butyrolactone: A quest for a practical route to an important hydroxyethylene isostere chiron

Several approaches for the stereocontrolled introduction of a 2-propyl group into (4S)-hydroxymethyl-1,4-butyrolactone via cholate chemistry were investigated. A practical synthesis of the (2R)- and (2S)-isomers was developed.