19126-12-6

Upstream product

• 703-55-9 1-naphthylmagnesiumbromide 
• 6341-54-4 1-naphthylglycolic acid 
• 66-77-3 1-naphthaldehyde 
• 19126-06-8 Naphthyl-⁽¹⁾-trichlormethyl-carbinol-acetat 
• 78772-53-9 methyl 2-hydroxy-2-(naphthalen-1-yl)acetate 
• 67-56-1 methanol 
• 19126-05-7 2,2,2-trichloro-1-(naphthalen-1-yl)ethan-1-ol 
• 13158-05-9 (+/-)-Methyl α-methoxy-α-(1-naphthyl)acetate 

Downstream Products

• 1072091-78-1 N-(2-bromophenyl)-2-methoxy-N-methyl-2-(naphthalen-1-yl)acetamide 

Relevant academic research and scientific papers

Synthesis of novel proxyphylline derivatives with dual Anti-Candida albicans and anticancer activity

Three out of 16 newly synthesized 1,3-dimethylxanthine derivatives (proxyphylline analogues) exhibited consistencies between antifungal and anticancer properties. Proxyphylline possessing 1-(10H-phenothiazin-10-yl)propan-2-yl (6) and polybrominated benzimidazole (41) or benzotriazole moiety (42) remained selectively cidal against Candida albicans (lg R ≥ 3 at conc. of 31, 36 and 20 μM, respectively) however not against normal mammalian Vero cell line in vitro (IC50 ≥ 280 μM) and Galleria mellonella in vivo. These compounds also displayed moderate antineoplastic activity against human breast adenocarcinoma (MCF-7) cell line (EC50 = 80 μM) and high against peripheral blood T lymphoblast (CCRF-CEM) (EC50 = 6.3–6.5 μM). In addition, 6 and 42 exerted: (1) dual activity against fungal adhesion and damage mature biofilm; (2) necrosis of planktonic cells due to loss of membrane function and of structural integrity; (3) biochemical (inhibition of sessile cell respiration) and morphological changes in cell wall polysaccharide contents. Therefore, leading proxyphylline derivatives can be employed to prevent cancer-associated biofilm Candida infections.

Chiral N-heterocyclic carbene ligands for asymmetric catalytic oxindole synthesis

The Pd-catalysed asymmetric intramolecular α-arylation of amide enolates containing heteroatom substituents gives chiral 3-alkoxy or 3-aminooxindoles in high yield and with enantioselectivities up to 97% ee when a new chiral N-heterocyclic carbene ligand is used. The Royal Society of Chemistry.

Conformational Structure and Dynamics of Arylmethoxyacetates: DNMR Spectroscopy and Aromatic Shielding Effect

The ground state conformational geometry and energy of esters of (R)- and (S)-arylmethoxyacetic acids were evaluated from low temperature 1H and 13C NMR spectra and by means of MM, AM1, and aromatic shielding effect calculations.In solution, the title com