6341-54-4

Basic information

• Product Name: 1-Naphthaleneglycolic acid
• Synonyms: 1-Naphthaleneglycolic acid;1-Naphthylglycolic acid
• CAS NO: 6341-54-4
• Molecular Formula: C₁₂H₁₀O₃
• Molecular Weight: 202.21
• Mol File: 6341-54-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 80 °C
• Boiling Point: 428.9°C at 760 mmHg
• Flash Point: 227.3°C
• Appearance: /
• Density: 1.354g/cm³
• Vapor Pressure: 4.04E-08mmHg at 25°C
• Refractive Index: 1.685
• PKA: 3.42±0.30(Predicted)
• CAS DataBase Reference: 1-Naphthaleneglycolic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Naphthaleneglycolic acid(6341-54-4)
• EPA Substance Registry System: 1-Naphthaleneglycolic acid(6341-54-4)

Safety Data

• Hazardous Substances Data: 6341-54-4(Hazardous Substances Data)

Usage

General Description

1-Naphthaleneglycolic acid, also known as 1-naphthylglycolic acid, is a chemical compound with the molecular formula C12H10O3. It is a white crystalline solid that is soluble in organic solvents. 1-Naphthaleneglycolic acid is used as a building block in the synthesis of pharmaceuticals, agrochemicals, and dyes. It also has applications in the field of organic synthesis, specifically in the formation of carbon-carbon bonds. 1-Naphthaleneglycolic acid is known for its role as an intermediate in the production of various derivatives and is commonly used for research and development purposes in the chemical industry. It is important to handle this chemical with care, as it may cause irritation to the skin, eyes, and respiratory system if not properly handled.

InChI:InChI=1/C12H10O3/c13-11(12(14)15)10-7-3-5-8-4-1-2-6-9(8)10/h1-7,11,13H,(H,14,15)

Upstream product

• 91-20-3 naphthalene 
• 75-36-5 acetyl chloride 
• 64-17-5 ethanol 
• 201230-82-2 carbon monoxide 
• 90-11-9 1-Bromonaphthalene 
• 74-88-4 methyl iodide 

Downstream Products

• 19126-12-6 methoxy(naphthalen-1-yl)acetic acid 
• 1158519-67-5 C₁₉H₁₄F₃NO₂ 
• 17066-45-4 (R)-Hydroxy-(naphthyl-⁽¹⁾)-essigsaeure-((1R)-menthylester) 
• 17066-45-4 (S)-Hydroxy-(naphthyl-⁽¹⁾)-essigsaeure-((1R)-menthylester) 
• 66-77-3 1-naphthaldehyde 

Relevant articles and documents

Normal Pressure Double Carbonylation of Aryl Halides Using Cobalt(II) Chloride in the Presence of either Sodium Sulfide or Sodium Borohydride

Tetracarbonylcobaltate ion generated by a treatment of cobalt(II) chloride with either sodium sulfide or sodium borohydride under a normal pressure of carbon monoxide was capable of catalyzing carbonylation of aryl halides in the presence of calcium hydroxide and methyl iodide to give arylglyoxylic acids in good selectivity.

ONE-STEP SYNTHESIS OF α-HYDROXY ACIDS VIA REDUCTIVE DOUBLE CARBONYLATION OF ORGANIC HALIDES

Palladium-catalyzed carbonylation of organic halides with water in the presence of calcium hydroxide or lithium hydroxide in primary or secondary alcoholic solvents afforded α-hydroxy acids.