191276-24-1Relevant academic research and scientific papers
Synthesis and evaluation of C-seco paclitaxel analogues
Appendino, Giovanni,Danieli, Bruno,Jakupovic, Jasmin,Belloro, Emanuela,Scambia, Giovanni,Bombardelli, Ezio
, p. 4273 - 4276 (1997)
Starting from 7,9diTes-10-dehydro C-secobaccatin III (4a), C-seco analogues of paclitaxel retaining biological activity were synthesised.
The Reductive Fragmentation of 7-Hydroxy-9,10-dioxotaxoids
Appendino, Giovanni,Noncovich, Alain,Bettoni, Piergiorgio,Dambruoso, Paolo,Sterner, Olov,Fontana, Gabriele,Bombardelli, Ezio
, p. 4422 - 4431 (2007/10/03)
The retro-aldol reductive fragmentation of different structural types of 7-hydroxy-9,10-dioxotaxoids was investigated, showing that the reaction is typical of taxanes and requires cerium(III) promotion with NaBH4 in protic medium and alkylboron (aluminium) hydrides in aprotic solvents. The resulting 7,8-seco-taxanes are key intermediates for the synthesis of a novel class of anticancer taxanes endowed with a unique pattern of in vivo biological activity. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.
