19128-84-8

Basic information

• Product Name: butanoic acid, 2-phenoxy-, (2R)-
• Synonyms: (2R)-2-Phenoxybutanoic acid
• CAS NO: 19128-84-8
• Molecular Formula: C₁₀H₁₂O₃
• Molecular Weight: 180.2005
• Mol File: 19128-84-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 257.999°C at 760 mmHg
• Flash Point: 115.327°C
• Density: 1.141g/cm³
• Vapor Pressure: 0.007mmHg at 25°C
• Refractive Index: 1.524
• CAS DataBase Reference: butanoic acid, 2-phenoxy-, (2R)-(CAS DataBase Reference)
• NIST Chemistry Reference: butanoic acid, 2-phenoxy-, (2R)-(19128-84-8)
• EPA Substance Registry System: butanoic acid, 2-phenoxy-, (2R)-(19128-84-8)

Safety Data

• Hazardous Substances Data: 19128-84-8(Hazardous Substances Data)

Upstream product

• 937025-54-2 (Z)-α-phenoxybutenoic acid 
• 108-95-2 phenol 
• 13794-14-4 2-phenoxybutyric acid 

Downstream Products

• 87810-50-2 (R)-2-ethyl-2-penoxyethanol 

Relevant articles and documents

Asymmetric hydrogenation of α,β-unsaturated carboxylic acids catalyzed by ruthenium(II) complexes of spirobifluorene diphosphine (SFDP) ligands

The ruthenium diacetate complexes ligated by chiral spirobifluorene diphosphines (SFDP) were very effective catalysts for the asymmetric hydrogenation of tiglic acid derivatives and α-methylcinnamic acid derivatives with high activities and excellent enantioselectivities (up to 98% ee). The α-aryloxybutenoic acids can also be hydrogenated by these catalysts to provide the corresponding saturated α-aryloxybutanoic acids in high yields (89-93%) and enantioselectivities (up to 95% ee). In this reaction, the SFDP ligand with para-methyl groups on the P-phenyl rings gave the best results.

Enzymatic enantioselective ester hydrolysis by carboxylesterase NP

The enzymatic hydrolysis of a series of carboxylic esters by carboxylesterase NP has been investigated in order to determine the scope and limitations of this enzyme. 2-Substituted propionates were hydrolyzed with high enantioselectivity when an aromatic moiety was part of the 2-substituent.Enantioselective hydrolysis could be accomplished with several 2-arypropionates, 2-(aryloxy)propionates and N-arylalanine esters.The propionate esters yielded propionic acids as (S) enantiomers, whereas the alanine esters yielded the (R) enantiomers.Without a 2-aryl substituent, the enzymatic hydrolysis of the propionates occurred at a lower rate without acceptable enantioselectivity.In addition to 2-substituted propionates, only a few other esters were hydrolyzed with high enantioselectivity by carboxylesterase NP, such as some prochiral disubstituted malonates. 1-Phenylethylacetate was the only substrate with chirality in the alcohol part of the ester that was found to be hydrolyzed enantioselectively.Carboxylesterase NP proved to be a powerful enzyme for kinetic resolution of propionate esters with an aromatic ring containing a 2-substituent.