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191338-86-0

AC-IETD-CHO is a small molecule chemical compound that functions as a caspase inhibitor, specifically targeting caspase-8 and caspase-10. It is characterized by its ability to irreversibly bind to the active sites of these enzymes, thereby inhibiting their activity. AC-IETD-CHO is widely recognized for its role in research settings, where it is used to explore the mechanisms of apoptosis, a form of programmed cell death. Its specificity and efficacy in blocking caspase activity have positioned AC-IETD-CHO as a valuable tool in both cell biology and pharmacology research, with potential therapeutic applications in conditions characterized by dysregulated apoptosis.

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  • L-Threoninamide,N-acetyl-L-isoleucyl-L-a-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]-

    Cas No: 191338-86-0

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  • L-Threoninamide,N-acetyl-L-isoleucyl-L-a-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]-

    Cas No: 191338-86-0

  • USD $ 1.0-1.0 / Metric Ton

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  • 191338-86-0 Structure

  • Basic information

    1. Product Name: AC-IETD-CHO
    2. Synonyms: GRANZYME B INHIBITOR II, CELL-PERMEABLE;AC-ALA-ALA-VAL-ALA-LEU-LEU-PRO-ALA-VAL-LEU-LEU-ALA-LEU-LEU-ALA-PRO-ILE-GLU-THR-ASP-CHO;ACETYL-L-ISOLEUCYL-L-GLUTAMYL-L-THREONYL-L-ASPART-1-AL;AC-ILE-GLU-THR-ASP-ALDEHYDE;AC-ILE-GLU-THR-ASP-ALDEHYDE (PSEUDO ACID);AC-ILE-GLU-THR-ASP-CHO;AC-ILE-GLU-THR-ASP-H (ALDEHYDE);AC-IETD-ALDEHYDE
    3. CAS NO:191338-86-0
    4. Molecular Formula: C21H34N4O10
    5. Molecular Weight: 502.52
    6. EINECS: N/A
    7. Product Categories: Caspases/Apoptosis;Pepetides;peptides
    8. Mol File: 191338-86-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: white/powder
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: −20°C
    8. Solubility: H2O: 1 mg/mL
    9. CAS DataBase Reference: AC-IETD-CHO(CAS DataBase Reference)
    10. NIST Chemistry Reference: AC-IETD-CHO(191338-86-0)
    11. EPA Substance Registry System: AC-IETD-CHO(191338-86-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 191338-86-0(Hazardous Substances Data)

191338-86-0 Usage

Uses

Used in Research Settings:
AC-IETD-CHO is used as a research tool for studying the mechanisms of apoptosis, particularly focusing on the role of caspase-8 and caspase-10 in programmed cell death pathways. Its ability to irreversibly inhibit these caspases makes it a valuable asset in understanding the intricate processes involved in cell death and survival.
Used in Therapeutic Applications:
AC-IETD-CHO is used as a potential therapeutic agent for conditions that involve dysregulated apoptosis. By inhibiting the activity of caspase-8 and caspase-10, it may help in managing diseases where apoptosis is either overactive or insufficient, contributing to the development of novel treatment strategies.
Used in Cell Biology Research:
In cell biology, AC-IETD-CHO is used as a specific inhibitor to confirm the involvement of caspase-8 and caspase-10 in cell death pathways. Its specificity allows researchers to accurately assess the contribution of these caspases to various biological processes and diseases, enhancing the understanding of cell death mechanisms and their regulation.
Used in Pharmacology Research:
AC-IETD-CHO serves as a crucial tool in pharmacology research, where it is employed to investigate the effects of various drugs and compounds on apoptosis. By inhibiting caspase-8 and caspase-10, researchers can evaluate the impact of potential therapeutic agents on cell death pathways, aiding in the development of new drugs and treatment approaches for a range of diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 191338-86-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,1,3,3 and 8 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 191338-86:
(8*1)+(7*9)+(6*1)+(5*3)+(4*3)+(3*8)+(2*8)+(1*6)=150
150 % 10 = 0
So 191338-86-0 is a valid CAS Registry Number.

191338-86-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name AC-IETD-CHO

1.2 Other means of identification

Product number -
Other names AC-ILE-GLU-THR-ASP-ALDEHYDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:191338-86-0 SDS

191338-86-0Downstream Products

191338-86-0Relevant articles and documents

Solid phase synthesis of aspartyl peptide aldehydes

Tong,Hong

, p. 8857 - 8860 (2000)

An efficient method for the solid phase synthesis of aspartyl aldehyde peptides has been developed. It uses a low cost synthetic process for the preparation of Fmoc-protected Weinreb amide linker. This procedure covers several tetrapeptide aspartyl aldehydes as well as biotinylated tetrapeptide aspartyl aldehydes. (C) 2000 Elsevier Science Ltd.

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