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Basic Information
CAS No.: 191338-86-0
Name: AC-IETD-CHO
Molecular Structure:
Molecular Structure of 191338-86-0 (AC-IETD-CHO)
Formula: C21H34N4O10
Molecular Weight: 502.522
Synonyms: Ac-Ile-Glu-Thr-Asp-CHO;
Solubility: H2O: 1 mg/mL
Appearance: white powder
PSA: 228.30000
LogP: -0.52560
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Chemistry

MF: C21H34N4O10
MW: 502.52
Solubility: H2O: 1 mg/mL
Appearance: white powder
Product Categories: Caspases/Apoptosis
IUPAC Name: 4-[(2-Acetamido-3-methylpentanoyl)amino]-5-[[3-hydroxy-1-[(4-hydroxy-1,4-dioxobutan-2-yl)amino]-1-oxobutan-2-yl]amino]-5-oxopentanoic acid
Synonyms: Caspase 6/caspase 8 inhibitor W-1 ; caspase-8 / caspase-3 processing enzyme inhibitor (aldehyde) ; Caspase 8 inhibitor I ; caspase-8 inhibitor I, cell-permeable ; Caspase-3 processing enzyme inhibitor  I(aldehyde) ; Ietd-cho, cell-permeable ; Granzyme b inhibitor (aldehyde)
Following is the molecular structure of AC-IETD-CHO (CAS NO.191338-86-0):

Uses

The Ac-IETD-CHO (CAS NO.191338-86-0) inhibitor may be used in protease assays like those described in the literature. When the caspase-8 fluorogenic substrate.
 Ac-IETD-AFC is treated with apoptotic cell lysates or with purified, active caspase-8, AFC is released. AFC release can be monitored in a spectrofluorometer at an excitation wavelength of 400 nm and an emission wavelength range of 480-520 nm. Apoptotic cell lysates yield a considerable emission as compared to non-apoptotic cell lysates, or apoptotic lysates, which also contain Ac-IETD-CHO. The amount of cell lysate required for protease assays will vary between experimental systems and should be optimized by the user.

Safety Profile

Safety Information of AC-IETD-CHO (CAS NO.191338-86-0):
WGK Germany: 3