19137-96-3Relevant academic research and scientific papers
Copper-catalyzed aerobic decarboxylative coupling between cyclic α-amino acids and diverse C-H nucleophiles with low catalyst loading
Guo, Jing,Xie, Ying,Wu, Qiao-Lei,Zeng, Wen-Tian,Chan, Albert S. C.,Weng, Jiang,Lu, Gui
, p. 16202 - 16206 (2018/05/22)
An aerobic decarboxylative cross-coupling of α-amino acids with diverse C-H nucleophiles has been realized using Cu2(OH)2CO3 (1 mol%) as the catalyst under air. This protocol enables highly efficient formation of various C
Condensations based on 5-(indol-3-yl)-pyrrolidin-2-thiones
Sadovoy, Andrey V.,Kattsyna, Veronica V.,Protopopova, Polina S.,Nelyubina, Yulia V.,Pavlov, Alexander A.,Kochetkov, Konstantin A.,Sviridova, Lyudmila A.
, (2018/11/25)
New activated indolylpyrrolidones—their methylthiopyrrolinium salts—in the reactions with several CH-acids were studied. 2-Nitromethylene- and 2-dicyanomethyleneindolylpyrrolidines were obtained from 5-indolyl-2-methylthiopyrrolinium salts with good yields. The reduction in these nitro compounds yields the respective aminomethylpyrolidines. The rigid structure of the starting compounds has significant stereoelectronic requirements of nucleophilic agents.
Biomimetic Approach toward the Total Synthesis of rac-2-(Acylmethylene)pyrrolidine Alkaloids
Shih, Yu-Chiao,Tsai, Pei-Hua,Hsu, Chia-Chun,Chang, Chih-Wei,Jhong, Yuandong,Chen, Yun-Chung,Chien, Tun-Cheng
, p. 6669 - 6678 (2015/10/06)
2-(Acylmethylene)pyrrolidine derivatives were synthesized via intermolecular decarbonylative Mannich reaction from various methyl ketones and 1-alkyl-1-pyrroliniums, generated in situ from 1-alkylprolines. This approach mimics the biosynthetic pathway and provides a direct access to a series of 2-(acylmethylene)pyrrolidine alkaloids, including hygrine, N-methylruspolinone, dehydrodarlinine, and ruspolinone.
Nontraditional reactions of azomethine ylides: Decarboxylative three-component couplings of α-amino acids
Zhang, Chen,Seidel, Daniel
supporting information; experimental part, p. 1798 - 1799 (2010/04/25)
(Formula Presented) New reactions of azomethine ylides with nontraditional dipolarophiles are reported. Azomethine ylides, formed in situ via decarboxylative condensations of α-amino acids with aldehydes, undergo reactions with naphthols, indoles, alkynes
