19137-96-3Relevant articles and documents
Condensations based on 5-(indol-3-yl)-pyrrolidin-2-thiones
Sadovoy, Andrey V.,Kattsyna, Veronica V.,Protopopova, Polina S.,Nelyubina, Yulia V.,Pavlov, Alexander A.,Kochetkov, Konstantin A.,Sviridova, Lyudmila A.
, (2018/11/25)
New activated indolylpyrrolidones—their methylthiopyrrolinium salts—in the reactions with several CH-acids were studied. 2-Nitromethylene- and 2-dicyanomethyleneindolylpyrrolidines were obtained from 5-indolyl-2-methylthiopyrrolinium salts with good yields. The reduction in these nitro compounds yields the respective aminomethylpyrolidines. The rigid structure of the starting compounds has significant stereoelectronic requirements of nucleophilic agents.
Biomimetic Approach toward the Total Synthesis of rac-2-(Acylmethylene)pyrrolidine Alkaloids
Shih, Yu-Chiao,Tsai, Pei-Hua,Hsu, Chia-Chun,Chang, Chih-Wei,Jhong, Yuandong,Chen, Yun-Chung,Chien, Tun-Cheng
, p. 6669 - 6678 (2015/10/06)
2-(Acylmethylene)pyrrolidine derivatives were synthesized via intermolecular decarbonylative Mannich reaction from various methyl ketones and 1-alkyl-1-pyrroliniums, generated in situ from 1-alkylprolines. This approach mimics the biosynthetic pathway and provides a direct access to a series of 2-(acylmethylene)pyrrolidine alkaloids, including hygrine, N-methylruspolinone, dehydrodarlinine, and ruspolinone.
Synthesis and pharmacological activity of 3-(2-pyrrolidinyl)indoles
Youngdale et al.
, p. 415,424 (2007/10/05)
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