19137-96-3Relevant academic research and scientific papers
Condensations based on 5-(indol-3-yl)-pyrrolidin-2-thiones
Sadovoy, Andrey V.,Kattsyna, Veronica V.,Protopopova, Polina S.,Nelyubina, Yulia V.,Pavlov, Alexander A.,Kochetkov, Konstantin A.,Sviridova, Lyudmila A.
, (2018/11/25)
New activated indolylpyrrolidones—their methylthiopyrrolinium salts—in the reactions with several CH-acids were studied. 2-Nitromethylene- and 2-dicyanomethyleneindolylpyrrolidines were obtained from 5-indolyl-2-methylthiopyrrolinium salts with good yields. The reduction in these nitro compounds yields the respective aminomethylpyrolidines. The rigid structure of the starting compounds has significant stereoelectronic requirements of nucleophilic agents.
Copper-catalyzed aerobic decarboxylative coupling between cyclic α-amino acids and diverse C-H nucleophiles with low catalyst loading
Guo, Jing,Xie, Ying,Wu, Qiao-Lei,Zeng, Wen-Tian,Chan, Albert S. C.,Weng, Jiang,Lu, Gui
, p. 16202 - 16206 (2018/05/22)
An aerobic decarboxylative cross-coupling of α-amino acids with diverse C-H nucleophiles has been realized using Cu2(OH)2CO3 (1 mol%) as the catalyst under air. This protocol enables highly efficient formation of various C
Biomimetic Approach toward the Total Synthesis of rac-2-(Acylmethylene)pyrrolidine Alkaloids
Shih, Yu-Chiao,Tsai, Pei-Hua,Hsu, Chia-Chun,Chang, Chih-Wei,Jhong, Yuandong,Chen, Yun-Chung,Chien, Tun-Cheng
, p. 6669 - 6678 (2015/10/06)
2-(Acylmethylene)pyrrolidine derivatives were synthesized via intermolecular decarbonylative Mannich reaction from various methyl ketones and 1-alkyl-1-pyrroliniums, generated in situ from 1-alkylprolines. This approach mimics the biosynthetic pathway and provides a direct access to a series of 2-(acylmethylene)pyrrolidine alkaloids, including hygrine, N-methylruspolinone, dehydrodarlinine, and ruspolinone.
Nontraditional reactions of azomethine ylides: Decarboxylative three-component couplings of α-amino acids
Zhang, Chen,Seidel, Daniel
supporting information; experimental part, p. 1798 - 1799 (2010/04/25)
(Formula Presented) New reactions of azomethine ylides with nontraditional dipolarophiles are reported. Azomethine ylides, formed in situ via decarboxylative condensations of α-amino acids with aldehydes, undergo reactions with naphthols, indoles, alkynes
