19141-19-6

Upstream product

• 5689-74-7 (1,3-diphenylpropyl)amine 
• 75-36-5 acetyl chloride 
• 1029700-77-3 (R)-2-methyl-N-((R)-3-phenyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propyl)propane-2-sulfinamide 
• 508225-73-8 (R)-N-(tert-butanesulfinyl)-N-(3-phenylpropyliden)amine 
• 104-53-0 3-phenyl-propionaldehyde 
• 108-86-1 bromobenzene 
• 108-24-7 acetic anhydride 
• 108-90-7 chlorobenzene 
• 165904-22-3 4,4,5,5-tetramethyl-2-phenethyl-1,3,2-dioxaborolane 
• 1083-30-3 dihydrochalcone 

Relevant academic research and scientific papers

Six-membered bis(azaphosphorinane), readily available ligand for highly enantioselective asymmetric hydrogenations

A new six-membered bis(azaphosphorinane) ligand has been readily prepared starting from an inexpensive chiral epoxide; excellent enantioselectivities (up to over 99% ee) have been achieved in the Rh-catalyzed asymmetric hydrogenations of β-dehydroamino ac

Enantiospecific Suzuki–Miyaura Coupling of Nonbenzylic α-(Acylamino)alkylboronic Acid Derivatives

Suzuki–Miyaura coupling of nonbenzylic α-(acylamino)alkylboron compounds with aryl halides is established. A Pd/PCy2Ph catalyst promotes the reaction efficiently at 145 °C. The reaction of enantioenriched α-(acylamino)alkylboron compounds affords chiral 1-arylalkylamides in high enantiospecificity and inversion of configuration.

A chiral 1,2-bisphospholane ligand with a novel structural motif: Applications in highly enantioselective Rh-catalyzed hydrogenations

TangPhos (1) is a highly efficient and practical ligand for asymmetric hydrogenations. High enantioselectivities and turnover numbers were observed in the Rh-catalyzed hydrogenation of α-(acylamino) acrylic acids and α-arylenamides.

Asymmetric synthesis of α-branched primary amines on solid support via novel hydrazine resins

Matrix presented Two novel chiral hydrazine resins for asymmetric solid-phase synthesis have been developed. The enantiopure β-methoxyamino auxiliaries, derived from frans-4-hydroxy-(S) -proline and (R) -leucine, were attached to Merrifield resin and transformed into their corresponding hydrazines. Immobilization of various aldehydes, followed by 1,2-addition of organolithium reagents to the resulting enantiopure hydrazones and reductive cleavage from the solid support, furnished α-branched amines, which were isolated as their corresponding amides in good overall yields and enantiomeric excesses of up to 86%.

Synthesis of a novel chiral binaphthyl phospholane and its application in the highly enantioselective hydrogenation of enamides.

[formula: see text] A new chiral phosphine, (R,R)-1,2-bis[(R)-4,5-dihydro-3H-dinaphtho[2,1- c:1',2'-e]phosphepino]benzene [abbreviated as (R,R)-binaphane] was prepared on the basis of a practical route from a readily accessible enantiomerically pure binap

A convenient asymmetric synthesis of α-1-arylalkylamines through the enantioselective hydrogenation of enamides

We have found that cationic Rh catalysts based on our 1,2-bis(trans-2,5 dimethylphospholano)benzene (Me-DuPHOS) and 1,2-bis(trans-2,5-dimethylphospholano)ethane (Me-BPE) ligands effect the hydrogenation of N-acetyl α-arylenamides (1, R = H) to yield a wid