19145-72-3Relevant academic research and scientific papers
An Unconventional Reaction of 2,2-Diazido Acylacetates with Amines
H?ring, Andreas P.,Biallas, Phillip,Kirsch, Stefan F.
supporting information, p. 1526 - 1539 (2017/04/01)
We have discovered that 2,2-diazido acylacetates, a class of compounds with essentially unknown reactivity, can be coupled to amines through a new strategy that does not involve any reagents. 2,2-Diazido acetate is the unconventional leaving group under carbon–carbon bond cleavage. This reaction leads to the construction of amide bonds, tolerates various functionalities and is performed equally well in numerous solvents under experimentally simple conditions. We also demonstrate that the isolation of the 2,2-diazido acylacetate compounds can be circumvented: Acylacetates were easily fragmented when treated with (Bu4N)N3 and iodine in the presence of an amine at room temperature. By using this method, a broad range of acylacetates with various structural motifs were directly transformed into amides.
Copper-Catalyzed Reductive N-Alkylation of Amides with N-Tosylhydrazones Derived from Ketones
Xu, Peng,Qi, Fu-Ling,Han, Fu-She,Wang, Yan-Hua
, p. 2030 - 2034 (2016/07/28)
A CuI-catalyzed reductive coupling of ketone-derived N-tosylhydrazones with amides is presented. Under the optimized conditions, an array of N-tosylhydrazones derived from aryl–alkyl and diaryl ketones could couple effectively with a wide variety of (hete
1H NMR SPECTRA OF SOME JUVABIONE ANALOGUES
Mahajan, R. K.,Gupta, Neelam,Uppal, Satinder K.
, p. 690 - 696 (2007/10/02)
A number of aromatic aza-analogues of juvabione and dehydrojuvabione have been synthetized by treatment of substituted benzylamine with 3-methylbutanoyl chloride and 3-methyl-2-butenoyl chloride.Reaction of substituted phenoxyacetyl chlorides with isoprop
