191595-63-8

Basic information

• Product Name: 2-HYDROXY-6-(TRIFLUOROMETHYL)NICOTINICACID
• Synonyms: 3-carboxyl-6-trifluoromethyl-1H-pyridin-2-one;2-Hydroxy-6-triflroromethylnicotinic acid;2-Hydroxy-6-(trifluoromethyl)nicotinic acid;2-Hydroxy-6-triflroroMethyl-3-pyridinecarboxylic acid;2-Hydroxy-6-(trifluoromethyl)pyridine-3-carboxylic acid, 3-Carboxy-2-hydroxy-6-(trifluoromethyl)pyridine;2-oxo-6-(trifluoromethyl)-1H-pyridine-3-carboxylic acid;2-Hydroxy-6-(trifluromethyl)nicotinicacid
• CAS NO: 191595-63-8
• Molecular Formula: C7H4F3NO3
• Molecular Weight: 207.11
• EINECS: 1312995-182-4
• Product Categories: Carboxylic Acids;Pyridines;Carboxylic Acids;carboxylic acid
• Mol File: 191595-63-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 165-167°C
• Boiling Point: 372.484 °C at 760 mmHg
• Flash Point: 179.072 °C
• Appearance: /
• Density: 1.629 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.512
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 2-HYDROXY-6-(TRIFLUOROMETHYL)NICOTINICACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-6-(TRIFLUOROMETHYL)NICOTINICACID(191595-63-8)
• EPA Substance Registry System: 2-HYDROXY-6-(TRIFLUOROMETHYL)NICOTINICACID(191595-63-8)

Safety Data

• Hazardous Substances Data: 191595-63-8(Hazardous Substances Data)

Usage

General Description

2-HYDROXY-6-(TRIFLUOROMETHYL)NICOTINICACID is a chemical compound that contains a nicotinic acid backbone with a hydroxyl group at the 2 position and a trifluoromethyl group at the 6 position. It is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals due to its unique structural features, including its ability to act as a chelating agent for metal ions. 2-HYDROXY-6-(TRIFLUOROMETHYL)NICOTINICACID has also been investigated for its potential antioxidant and anti-inflammatory properties, making it an interesting target for further research in the fields of medicinal chemistry and drug development.

InChI:InChI=1/C7H4F3NO3/c8-7(9,10)4-2-1-3(6(13)14)5(12)11-4/h1-2H,(H,11,12)(H,13,14)

Upstream product

• 116548-03-9 2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamide 
• 144740-55-6 1,2-dihydro-2-oxo-6-(trifluoromethyl)pyridine-3-carboxylic acid methyl ester 
• 231291-22-8 6-trifluoromethylnicotinic acid 
• 116548-03-9 2-hydroxy-6-trifluoromethylpyridine-3-carboxamide 

Downstream Products

• 144740-55-6 methyl 2-hydroxy-6-(trifluoromethyl)nicotinate 
• 144740-56-7 methyl 2-bromo-6-(trifluoromethyl)nicotinate 
• 917396-37-3 [2-methoxy-6-(trifluoromethyl)pyridin-3-yl]methanol 
• 917396-36-2 methyl 2-methoxy-6-(trifluoromethyl)nicotinate 

Relevant articles and documents

A tautomeric ligand enables directed C-H hydroxylation with molecular oxygen

Hydroxylation of aryl carbon-hydrogen bonds with transition metal catalysts has proven challenging when oxygen is used as the oxidant. Here, we report a palladium complex bearing a bidentate pyridine/ pyridone ligand that efficiently catalyzes this reaction at ring positions adjacent to carboxylic acids. Infrared, x-ray, and computational analysis support a possible role of ligand tautomerization from monoanionic (L,X) to neutral (L,L) coordination in the catalytic cycle of aerobic carbon-hydrogen hydroxylation reaction. The conventional site selectivity dictated by heterocycles is overturned by this catalyst, thus allowing late-stage modification of compounds of pharmaceutical interest at previously inaccessible sites.

PYRIDINECARBOXAMIDES, USEFUL-PLANT-PROTECTING COMPOSITION COMPRISING THEM AND PROCESSES FOR THEIR PREPARTION AND THEIR USE

Compounds of the formula (I), or salts thereof, in which R1 to R4 are as defined in formula (I) of claim 1 are suitable as useful-plant-protecting agents for reducing or preventing harmful effects of agrochemicals on the useful plants and their method of preparation are described.