191613-05-5

Upstream product

• 99395-88-7 (S)-4-phenyl-2-oxazolidinone 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 191613-06-6 (S)-3-(2-Phenethylsulfanyl-acetyl)-4-phenyl-oxazolidin-2-one 
• 99395-88-7 (S)-4-phenyl-2-oxazolidinone 
• 858104-45-7 (4S)-3-{2-[(4-methoxyphenyl)methylthio]acetyl}-4-phenyl-1,3-oxazolidin-2-one 
• 191613-07-7 (S)-3-[(2R,3R)-3-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-3-(4-fluoro-phenylamino)-2-phenethylsulfanyl-propionyl]-4-phenyl-oxazolidin-2-one 
• 204262-45-3 (S)-3-[(2R,3R)-3-(4-Methoxy-phenyl)-2-phenethylsulfanyl-3-phenylamino-propionyl]-4-phenyl-oxazolidin-2-one 

Relevant academic research and scientific papers

Synthesis of C3 heteroatom-substituted azetidinones that display potent cholesterol absorption inhibitory activity

The C3 phenylpropyl side chain N-phenylazetidinones related to SCH 56524 was modified by replacing the hydroxymethylene with various isoelectronic or isosteric groups. Modifications at the 3' position led to less-active compounds; however, modifications a

Stereoselective Visible-Light Catalyzed Cyclization of Bis(enones): A Viable Approach to the Synthesis of Enantiomerically Enriched Cyclopentane Rings

Photoredox catalytic cyclization of aryl enones in the presence of visible light, promoted either by metals or organic dyes, represent a valuable strategy for the synthesis of cycloalkanes. The development of a stereoselective version of such transformation, in the presence of the metal-free catalyst Eosin Y was studied, with the aim to realize an efficient protocol for the in-flow synthesis of enantiomerically enriched functionalized cyclopentane rings, taking advantage of the flow reactors technology. The use of a chiral auxiliary on the bisenone to be cyclized offers a straightforward and convenient option to exert a stereocontrol on the light-driven cyclization. By exploiting Evans’ oxazolidinones, the stereoselective light-driven cyclization affords, after the removal of the chiral auxiliary, a functionalized 1,2-trans cyclopentane ring in up to 83/17 enantiomeric ratio. When the reaction was performed in continuo, in a homemade coil photoreactor, high yields were observed. The cyclization was also successfully realized in a 3D-printed mesoreactor, without any change in the diastereoseletctivity of the process.

Synthesis and characterization of novel chiral imidazolium and pyridinium ionic liquids derived from tartaric acid and 2-oxazolidinone

Novel chiral imidazolium and pyridinium ionic liquids based on tartaric acid and 2-oxazolidinone were designed. Symmetrical dicationic ionic liquids based on tartaric acid have been synthesized and characterized. These chiral ionic liquids were designed b

METHOD FOR PRODUCING OPTICALLY ACTIVE CYCLIC AMINE DERIVATIVE OR SALT THEREOF

PROBLEM TO BE SOLVED: To provide a novel method for producing an optically active imidazole derivative having strong analgesic action on neuropathic pain, fibromyalgia or the like. SOLUTION: The present invention provides a method for producing an optically active imidazole derivative or a salt thereof comprising the following three steps (where, A is dialkylamino or 4-alkylpiperazine-1-yl group-substituted piperidinyl or pyrrolidinyl group; R1 is phenyl group, benzyl group or isopropyl group; R2 is fluorine-substitutable methyl or ethyl group; R4 is C1-3 alkyl group or the like). SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT

1-BIARYLAZETIDINONE DERIVATIVES

The object of the present invention is to provide a compound having an excellent cholesterol-lowering effect and to provide a drug for the treatment, prevention of onset, or prevention of progress of lipid metabolism disorder, hyperlipidemia, or atheroscl