19164-78-4Relevant academic research and scientific papers
Synthesis and stereochemical assignments of cis- and trans-1-amino-4-ethylcyclohexa-2,5-diene as models for amiclenomycin
Mann, Stephane,Carillon, Sophie,Breyne, Olivier,Duhayon, Carine,Hamon, Louis,Marquet, Andree
, p. 736 - 744 (2007/10/03)
As an approach to the synthesis of amiclenomycin (1), we describe here the synthesis of a 1-aminocyclohexa-2,5-diene moiety. The cis isomer 2 was obtained by means of a Diels - Alder reaction between trans-1,2-bis(phenylsulfonyl)ethylene and N-(allyloxyca
Acylation and related reactions under microwaves. 4. Sulfonylation reactions of aromatics
Marquie,Laporterie,Dubac,Roques,Desmurs
, p. 421 - 425 (2007/10/03)
Solvent-free sulfonylation of benzene and its activated or deactivated derivatives were carried out under microwave (MW) irradiation and a catalytic amount of iron(III) chloride, which, under these conditions, is more, active than other metallic salts. With more reactive and/or nonvolatile reagents (anisole, xylenes, mesitylene) expeditious conditions (short reaction time at constant MW power without control of the temperature) were used. With less reactive and/or low-boiling reagents (benzene, toluene, halobenzenes), the rise in temperature and the increase of reaction time were controlled either by sequential MW irradiation or by a temperature order. It was shown that MWs cause preferential interactions with polar species present in the reaction, especially the aryl sulfone and its FeCl3-complexed form. A MW nonthermal effect was not observed when identical temperature gradients were produced by classical heating and MW irradiation, and if reaction temperature was strictly controlled.
