191655-31-9

Upstream product

• 191655-29-5 (S)-(3-benzyloxy-2-t-butoxycarbonylaminopropoxy)acetic acid t-butyl ester 
• 79069-15-1 N-(tert-butyloxycarbonyl)-O-benzyl-L-serinol 
• 23680-31-1 BOC-O-benzyl-L-serine 
• 4330-20-5 N-3-benzoylthymine 
• 191655-30-8 ((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propoxy)-acetic acid tert-butyl ester 

Relevant academic research and scientific papers

Polyamide based nucleic acid analogs synthesis of δ-amino acids with nucleic acid bases bearing side chains

Nucleoamino acids of type I-III have been synthesized, which can serve as building blocks for novel polyamide based nucleic acid analogs. Key steps in the syntheses are the alkylation of serinol I and homoserinol 18 with tert-butyl bromoacetate or tert-butyl bromopropionate under phase transfer conditions and the introduction of thymine or uracil into the amino acid side drains by way of a Mitsunobu reaction. Cytosine derivatives were prepared through uracil → cytosine base conversion at the stage of N(δ)-BOC protected amino acid tert-butyl esters.