191727-50-1

Upstream product

• 879373-79-2 1-(2-chloropyridin-5-yl)-3-dimethylamino-2-propen-1-one 
• 55676-22-7 3-acetyl-6-chloropyridine 

Downstream Products

• 207282-09-5 4-(2-(3-(R,S)-Methylpiperazin-1-yl)pyridin-5-yl)-N-(3,4,5-trimethoxyphenyl)-2-pyrimidineamine 

Relevant academic research and scientific papers

4-pyridin-5-yl-2-(3,4,5-trimethoxyphenylamino)pyrimidines: Potent and selective inhibitors of ZAP 70

Activation of the tyrosine kinase ZAP 70 has been shown to be crucial to the transduction of the T-cell receptor signalling pathway, which leads ultimately to proliferation, cytokine gene expression and T-cell effector functions. A series of 2-phenylaminopyrimidines have been identified as potent and selective inhibitors of ZAP 70.