207282-09-5

Upstream product

• 109-07-9 (RS)-2-methylpiperazine 
• 191727-50-1 4-(2-Chloropyridin-5-yl)-N-(3,4,5-trimethoxyphenyl)-2-pyrimidineamine 
• 55676-22-7 3-acetyl-6-chloropyridine 
• 879373-79-2 1-(2-chloropyridin-5-yl)-3-dimethylamino-2-propen-1-one 

Relevant academic research and scientific papers

4-pyridin-5-yl-2-(3,4,5-trimethoxyphenylamino)pyrimidines: Potent and selective inhibitors of ZAP 70

Activation of the tyrosine kinase ZAP 70 has been shown to be crucial to the transduction of the T-cell receptor signalling pathway, which leads ultimately to proliferation, cytokine gene expression and T-cell effector functions. A series of 2-phenylaminopyrimidines have been identified as potent and selective inhibitors of ZAP 70.

2-Pyrimidineamine derivatives and processes for their preparation

Compounds of general formula (1) are described wherein: Ar is an optionally substituted aromatic group; R2 is a hydrogen or halogen atom or a group -X1-R2a where X1 is a direct bond or a linker atom or group, and R2a is an optionally substituted straight or branched chain alkyl, alkenyl or alkynyl group; R3 is an optionally substituted heterocycloalkyl group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are selective protein tyrosine kinase inhibitors, particularly the kinases ZAP-70 and syk and are of use in the prophylaxis and treatment of immune or allergic diseases and diseases involving inappropriate platelet activation.