191731-32-5

Basic information

• Product Name: Acetamide, N-methoxy-2-[(4-methoxyphenyl)methoxy]-N-methyl-
• CAS NO: 191731-32-5
• Molecular Formula: C12H17NO4
• Molecular Weight: 239.271
• Mol File: 191731-32-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Acetamide, N-methoxy-2-[(4-methoxyphenyl)methoxy]-N-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-methoxy-2-[(4-methoxyphenyl)methoxy]-N-methyl-(191731-32-5)
• EPA Substance Registry System: Acetamide, N-methoxy-2-[(4-methoxyphenyl)methoxy]-N-methyl-(191731-32-5)

Safety Data

• Hazardous Substances Data: 191731-32-5(Hazardous Substances Data)

Upstream product

• 88920-24-5 p-methoxybenzyloxy acetic acid 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 67442-07-3 2-chloro-N-methoxy-N-methylacetamide 
• 105-13-5 4-Methoxybenzyl alcohol 

Downstream Products

• 1600512-80-8 (Z)-N-(1-(5-bromo-2-fluorophenyl)-2-((4-methoxybenzyl)oxy)ethylidene)-2-methylpropane-2-sulfinamide 
• 1600512-81-9 N-(2-(5-bromo-2-fluorophenyl)-1-((2-cyanopropan-2-yl)sulfonyl)-3-((4-methoxybenzyl)oxy)propan-2-yl)-2-methylpropane-2-sulfinamide 
• 1600512-79-5 1-(5-bromo-2-fluorophenyl)-2-((4-methoxybenzyl)oxy)ethanone 
• 1434713-46-8 1-((4-methoxybenzyl)oxy)-3-methylbutan-2-one 
• 1285607-96-6 C₁₆H₁₄O₂ 
• 1284219-06-2 C₁₇H₁₅F₃O₅S 
• 1284219-15-3 6-methoxy-1-phenyl-1H-inden-2(3H)-one 
• 1159374-12-5 C₁₆H₁₆O₃ 
• 1095223-12-3 1-(2-fluoro-pyridin-3-yl)-2-(4-methoxy-benzyloxy)-ethanone 
• 400063-08-3 2-(4-methoxy-benzyloxymethyl)-6-oxo-1,6-dihydro-[3,4']bipyridinyl-5-carbonitrile 
• 921209-92-9 4-(4-methoxybenzyloxy)-3-oxobutyric acid methyl ester 
• 482351-08-6 methyl (7R)-α-[[(4-methoxyphenyl)methoxy]acetyl]-1,4-dioxaspiro[4,5]decane-7-acetate 
• 400063-06-1 1-(4-methoxy-benzyloxy)-3-pyridin-4-yl-propan-2-one 

Relevant articles and documents

Facile KF/alumina mediated synthesis of α-heterosubstituted Weinreb amides

Anhydrous KF/alumina in dipolar aprotic solvents was found to be an effective promoter in the synthesis of α-heterosubstituted Weinreb amides prepared from 2-chloro-N-methoxy-N-methylacetamide. This method is high yielding, even for weak nucleophiles, and

[3,3]-sigmatropic rearrangement/5-exo-dig cyclization reactions of benzyl alkynyl ethers: Synthesis of substituted 2-indanones and indenes

Substituted benzyl alkynyl ethers, prepared from the corresponding α-alkoxy ketones in a two-step sequence involving enol triflate formation and KOtBu-induced E2 elimination, undergo [3,3]-sigmatropic rearrangement/ intramolecular 5-exo-dig cyclization at 60 °C to form substituted 2-indanones in good overall yields. 1,3-cis-Disubstituted-2-indanones are formed preferentially when the benzylic substituent R1 is bulky. Substituted indenes may be prepared from 2-indanones in high yields by Horner-Wadsworth-Emmons reaction.

Synthesis, crystal structure determination, and biological properties of the DNA-dependent protein kinase (DNA-PK) inhibitor 3-cyano-6-hydrazonomethyl-5-(4-pyridyl)pyrid-[1H]-2-one (OK-1035).

The first reported synthesis of the DNA-PK inhibitor 3-cyano-6-hydrazonomethyl-5-(4-pyridyl)pyrid-[1H]-2-one (OK-1035) is described. The structure of OK-1035 was validated by X-ray crystallography. An IC(50) value of 100 microM was determined for inhibition of DNA-PK, and this is approximately 12-fold higher than that reported previously.