19178-21-3Relevant articles and documents
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McCasland,Bryce
, p. 842 (1952)
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Microwave-assisted copper-powder-catalyzed synthesis of pyrimidinones from β-bromo α,β-unsaturated carboxylic acids and amidines
Ho, Son Long,Cho, Chan Sik
, p. 2705 - 2708 (2014/01/06)
β-Bromo α,β-unsaturated carboxylic acids were coupled and cyclized with amidine hydrochlorides by microwave irradiation in the presence of catalytic amounts of copper powder and a base to give the corresponding pyrimidinones in high yields. Georg Thieme Verlag Stuttgart New York.
Easy and efficient copper-catalyzed synthesis of bicyclic pyrimidinones under mild conditions
Guo, Qi,Yang, Haijun,Liu, Hongxia,Jiang, Yuyang,Fu, Hua
experimental part, p. 2611 - 2616 (2010/11/24)
A simple and efficient copper-catalyzed method has been developed for synthesis of bicyclic pyrimidinones containing six-, seven-, eight-membered rings under mild conditions. The protocol uses readily available 2-bromocycloalk-1-enecarboxylic acids, amidines, and guanidines as the starting materials, copper-catalyzed cascade couplings provide the corresponding bicyclic pyrimidinones without addition of any ligand or additive, and the method is of economical and practical advantages. Georg Thieme Verlag Stuttgart New York.