68965-62-8

Basic information

• Product Name: 1-Cyclohexene-1-carboxylic acid, 2-bromo-
• CAS NO: 68965-62-8
• Molecular Formula: C7H9BrO2
• Molecular Weight: 205.051
• Mol File: 68965-62-8.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 1-Cyclohexene-1-carboxylic acid, 2-bromo-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Cyclohexene-1-carboxylic acid, 2-bromo-(68965-62-8)
• EPA Substance Registry System: 1-Cyclohexene-1-carboxylic acid, 2-bromo-(68965-62-8)

Safety Data

• Hazardous Substances Data: 68965-62-8(Hazardous Substances Data)

Usage

General Description

1-Cyclohexene-1-carboxylic acid, 2-bromo- is a chemical compound with the molecular formula C8H11BrO2. It is an organic compound containing a cyclohexene ring and a carboxylic acid group with a bromine substituent at the 2-position. 1-Cyclohexene-1-carboxylic acid, 2-bromo- is often used in organic synthesis and in the production of pharmaceuticals and agrochemicals. It can also be used as a starting material for the synthesis of various derivatives and can be involved in a variety of chemical reactions. Its properties and reactivity make it a versatile and valuable compound in the field of organic chemistry.

Upstream product

• 108-94-1 cyclohexanone 
• 38127-47-8 2-bromocyclohex-1-ene-1-carbaldehyde 
• 72422-64-1 2-bromocyclohex-1-ene-1-carboxylic acid methyl ester 

Downstream Products

• 552857-10-0 2-bromo-N-phenyl-1-cyclohexene-1-carboxamide 
• 122135-92-6 (3Z)-4,5,6,7-tetrahydro-3-benzylideneisobenzofuran-1(3H)-one 
• 1601483-05-9 4,5,6,7-tetrahydro-2-(phenylamino)-2H-isoindole-1,3-dione 
• 72422-64-1 2-bromocyclohex-1-ene-1-carboxylic acid methyl ester 
• 121032-80-2 3-[1-p-Tolyl-meth-(E)-ylidene]-4,5,6,7-tetrahydro-3H-isobenzofuran-1-one 

Relevant articles and documents

SELECTIVE PHOSPHATASE INHIBITORS BASED ON ILLUDALIC ACID

The present disclosure provides novel selective phosphatase inhibitor compounds based on illudalic acid. The present disclosure provides a streamlined method of synthesizing illudalic acid and a method for synthesizing phosphatase inhibitor compounds. The method of this invention provides convergent benzannulation of β-keto amides and esters, followed by a one-pot reduction / hydrolysis sequence. The concise synthetic approach provided by this invention enables rapid assembly of illudalog compounds of this invention that are potent protein tyrosine phosphatase receptor-type D (PTPRD) inhibitors.

Structure-activity relationship study of non-steroidal NPC1L1 ligands identified through cell-based assay using pharmacological chaperone effect as a readout

Niemann-Pick type C1-like 1 (NPC1L1) is an intestinal cholesterol transporter that is known to be the target of the cholesterol absorption inhibitor ezetimibe. We previously discovered steroidal NPC1L1 ligands by using a novel cell-based assay that employs pharmacological chaperone effect as a readout. Those steroid derivatives bound to a site different from both the sterol-binding domain and the ezetimibe-binding site, implying that they may be a novel class of NPC1L1 inhibitors with a distinct mode of action. As an extension of that work, we aimed here to find non-steroidal NPC1L1 ligands, which may be better candidates for clinical application than steroidal ligands, by using the same assay to screen our focused library of ligands for liver X receptor (LXR), a nuclear receptor that recognizes oxysterols as endogenous ligands. Here we describe identification of a novel class of NPC1L1 ligands with a ring-fused quinolinone scaffold, and an analysis of the structure-activity relationships of their derivatives as NPC1L1 ligands.

Palladium-catalyzed carbonylative cyclization of β-Bromo-α, β-unsaturated carboxylic acids leading to maleic anhydrides

β-Bromo-α,β-unsaturated carboxylic acids are carbonylatively cyclized under carbon monoxide pressure in acetic acid in the presence of a catalytic amount of a palladium catalyst along with a base to give the corresponding maleic anhydrides in high yields. Georg Thieme Verlag Stuttgart · New York.