191793-76-7

Upstream product

• 191793-75-6 (S)-N-(9H-fluoren-9-ylmethyloxycarbonyl)-4-hydroxyproline methyl ester 
• 191793-72-3 (S)-4-Fluoro-pyrrolidine-2-carboxylic acid methyl ester 
• 88050-17-3 N-Fmoc-trans-4-Hydroxy-L-Proline 
• 122350-59-8 (2S,4R)-1-(9H-fluoren-9-yl)methyl-2-methyl-4-hydroxypyrrolidine-1,2-dicarboxylate 
• 102774-86-7 9-fluorenylmethyl N-succinimidyl carbonate 
• 191793-73-4 (S)-4-Fluoro-pyrrolidine-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester 2-methyl ester 

Relevant academic research and scientific papers

Fluorinated peptides incorporating a 4-fluoroproline residue as potential inhibitors of HIV protease

N-Fmoc-4-fluoro-L-proline methyl ester was prepared as an attractive synthon for both solid and solution phase peptide synthesis. Its use for the synthesis of Fmoc-Phe-Pro(F)-OMe and Fmoc-Pro(F)-Val-Val-OMe is presented. Direct fluorination with DAST of a