Fluorinated peptides incorporating a 4-fluoroproline residue as potential inhibitors of HIV protease

Article abstract of DOI:10.1016/S0022-1139(96)03568-3

N-Fmoc-4-fluoro-L-proline methyl ester was prepared as an attractive synthon for both solid and solution phase peptide synthesis. Its use for the synthesis of Fmoc-Phe-Pro(F)-OMe and Fmoc-Pro(F)-Val-Val-OMe is presented. Direct fluorination with DAST of a