19182-97-9Relevant articles and documents
Light-Controlled Tyrosine Nitration of Proteins
Long, Tengfang,Liu, Lei,Tao, Youqi,Zhang, Wanli,Quan, Jiale,Zheng, Jie,Hegemann, Julian D.,Uesugi, Motonari,Yao, Wenbing,Tian, Hong,Wang, Huan
supporting information, p. 13414 - 13422 (2021/05/12)
Tyrosine nitration of proteins is one of the most important oxidative post-translational modifications in vivo. A major obstacle for its biochemical and physiological studies is the lack of efficient and chemoselective protein tyrosine nitration reagents. Herein, we report a generalizable strategy for light-controlled protein tyrosine nitration by employing biocompatible dinitroimidazole reagents. Upon 390 nm irradiation, dinitroimidazoles efficiently convert tyrosine residues into 3-nitrotyrosine residues in peptides and proteins with fast kinetics and high chemoselectivity under neutral aqueous buffer conditions. The incorporation of 3-nitrotyrosine residues enhances the thermostability of lasso peptide natural products and endows murine tumor necrosis factor-α with strong immunogenicity to break self-tolerance. The light-controlled time resolution of this method allows the investigation of the impact of tyrosine nitration on the self-assembly behavior of α-synuclein.
Synthesis and in vitro growth inhibition of 2-allylphenol derivatives against Phythopthora cinnamomi rands
Olea, Andrés F.,Espinoza, Luis,Sedan, Claudia,Thomas, Mario,Martínez, Rolando,Mellado, Marco,Carrasco, Héctor,Díaz, Katy
, (2019/11/28)
Phytophthora cinnamomi is a phytopathogen that causes extensive damage in different crops, and therefore, produces important economic losses all around the world. Chemical fungicides are a key factor for the control of this disease. However, ecological an
Investigation on Claisen rearrangement of allyl phenyl ethers in near-critical water
Xiao, Shangyou,He, Yi,Xu, Guang,Liu, Qi
, p. 3299 - 3305 (2015/06/08)
Catalyst-free Clasien rearrangement of allyl phenyl ethers were investigated in near-critical water. The effects on the reaction in near-critical water and conventional conditions were compared. The results demonstrate that near-critical water could greatly accelerate the Claisen rearrangement of allyl phenyl ethers. This process is simple, fast, efficient and environmentally benign.
