191980-59-3Relevant academic research and scientific papers
Palladium(0)-catalyzed preparation of 4-arylpyrazoles
Elguero, Jose?,Jaramillo, Carlos,Pardo, Carmen
, p. 563 - 566 (1997)
A general method for the palladium(0)-catalyzed preparation of 4- arylpyrazoles 2, by coupling of either 4-halopyrazoles 3 with arylstannanes 4 or 4-tributylstannyl-1-tritylpyrazole 5 with aryl iodides 6, is reported. Deprotection of trityl and/or methyl
Synthesis of 4-aryl-1H-pyrazoles by Suzuki-Miyaura cross coupling reaction between 4-bromo-1H-1-trityl-pyrazole and arylboronic acids
Ichikawa, Hayato,Nishioka, Miho,Arimoto, Masao,Usami, Yoshihide
experimental part, p. 1509 - 1516 (2010/12/24)
A general procedure for the synthesis of 4-aryl-1H-pyrazoles by the Suzuki-Miyaura cross coupling reaction between 4-bromo-1H-1-tritylpyrazole and commercially available arylboronic acids was developed. Using this procedure, a direct synthesis of 4-aryl-1H-pyrazoles possessing functional groups, such as hydroxyl, nitro, and amino groups, on the aryl ring was realized. Those molecules could not be prepared by our previous synthesis of 4-aryl-1H-pyrazoles via the Kumada cross coupling reaction.
