192060-69-8Relevant academic research and scientific papers
Unified strategy for the synthesis of (-)-elisapterosin B and (-)-colombiasin A
Kim, Angie I.,Rychnovsky, Scott D.
, p. 1267 - 1270 (2003)
A biomimetic [5+2] cyclization of a serrulatane diene (1) forms the basis of a concise synthesis of (-)-elisapterosin B. The diene 1 was prepared in 15 steps by using a Diels-Alder reaction between an oxygenated diene and a quinone, followed by the introduction of the methyl group at C3. The same diene 1 was used to prepare the natural product (-)-colombiasin A by a thermal [4+2] cycloaddition and demethylation.
Total synthesis and neuritotrophic activity of farinosone C and derivatives
Jessen, Henning J.,Barbaras, Damien,Hamburger, Matthias,Gademann, Karl
supporting information; experimental part, p. 3446 - 3449 (2009/12/22)
An efficient synthesis of all four possible stereoisomers of the neurotrophic amide farinosone C was developed. The absolute and relative configuration was assigned by comparison of synthetic material with a derivatized authentic sample of the natural pro
Stereoselective syntheses of epothilones A and B via nitrile oxide cycloadditions and related studies
Bode,Carreira
, p. 6410 - 6424 (2007/10/03)
The expedient and fully stereocontrolled synthesis of epothilones A and B are described. The routes described make extensive study of nitrile oxide cycloadditions as surrogates for aldol addition reactions and have led to the realization of a highly convergent synthesis based on the Kanemasa hydroxyl-directed nitrile oxide cycloaddition. As well, our synthetic efforts have led to the development of new reaction methodologies and served as the proving ground for several modern methods for asymmetric carbon-carbon bond formation.
