192062-26-3Relevant academic research and scientific papers
2-alkoxy estradiols and derivatives thereof
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, (2008/06/13)
Compounds represented by the following structural formula: wherein R1, R2 and R3 are as defined in the specification. The compounds are disclosed as useful in the treatment of various forms of cancer.
Synthesis of analogs of 2-methoxyestradiol with enhanced inhibitory effects on tubulin polymerization and cancer cell growth
Cushman, Mark,He, Hu-Ming,Katzenellenbogen, John A.,Varma, Ravi K.,Hamel, Ernest,Lin, Chii M.,Ram, Siya,Sachdeva, Yesh P.
, p. 2323 - 2334 (2007/10/03)
A new series of estradiol analogs was synthesized in an attempt to improve on the anticancer activity of 2-methoxyestradiol, a naturally occurring mammalian tubulin polymerization inhibitor. The compounds were evaluated as inhibitors of tubulin polymeriza
