192062-25-2Relevant academic research and scientific papers
Synthesis and in vitro cytotoxicity of 2-substituted 17-methylene/17- β-methyl estratrienes
Panchapakesan, Ganapathy,Sureshbabu, Radhakrishnan,Nachiappan, Dhatchana Moorthy,Mohanakrishnan, Arasambattu K.
, p. 109 - 121 (2013/02/23)
Synthesis of 17-methylene/17-β-methyl estratrienes containing 2-alkylaminomethyl and 2-arylaminomethyl substituents is reported. These compounds are evaluated for their cytotoxicities against four different cell lines, colon, lung, glioma and breast cance
17β-HSD1 AND STS INHIBITORS
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Page/Page column 87, (2010/11/25)
The present invention relates to novel substituted steroid derivatives which represent selectiv inhibitors of the 17β-hydroxysteroid dehydrogenase type I (17β-HSD1) and, in addition, which may represent inhibitors of the steroid sulphatase, as well as to their salts, to pharmaceutical preparations containing these compounds and to processes for the preparation of these compounds. Furthermore, the invention concerns the therapeutic use of said novel substituted steroid derivatives, particularly their use in the treatment or prevention of steroid hormone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of 17β-hydroxysteroid dehydrogenase type I and/or steroid sulphatase enzymes and/or requiring the lowering of the endogenous 17β-estradiol concentration.
2-alkoxy estradiols and derivatives thereof
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, (2008/06/13)
Compounds represented by the following structural formula: wherein R1, R2 and R3 are as defined in the specification. The compounds are disclosed as useful in the treatment of various forms of cancer.
Synthesis of analogs of 2-methoxyestradiol with enhanced inhibitory effects on tubulin polymerization and cancer cell growth
Cushman, Mark,He, Hu-Ming,Katzenellenbogen, John A.,Varma, Ravi K.,Hamel, Ernest,Lin, Chii M.,Ram, Siya,Sachdeva, Yesh P.
, p. 2323 - 2334 (2007/10/03)
A new series of estradiol analogs was synthesized in an attempt to improve on the anticancer activity of 2-methoxyestradiol, a naturally occurring mammalian tubulin polymerization inhibitor. The compounds were evaluated as inhibitors of tubulin polymeriza
