1921-70-6 Usage
Chemical Properties
colourless liquid
Uses
Different sources of media describe the Uses of 1921-70-6 differently. You can refer to the following data:
1. Lubricant; transformer oil. Anti-corrosion agent. Biological marker. In experimental systems to induce plasmacytomas; in production of monoclonal antibodies.
2. Pristane is a hydrocarbon oil adjuvant.
3. Pristane has been used as an inflammation-inducing agent, leading to myeloma development in BALB/c strain mice. It has been used as a rheumatoid arthritis-inducing agent in rats.
Definition
ChEBI: A norterpene that is an acyclic saturated hydrocarbon derived from phytane by loss of its C-16 terminal methyl group.
General Description
Pristane is a natural saturated terpenoid alkane used in research on the pathogenesis of autoimmune diseases such as arthritis and lupus.
Biochem/physiol Actions
Pristane is a hydrocarbon oil adjuvant widely used to induce tumorigenesis in mice and arthritis and lupus nephritis in rats. It works as a adjuvant for monoclonal antibody generation in mouse ascites.
Purification Methods
Purify pristane by shaking it with conc H2SO4 (care, if amount of pristane is too small then it should be diluted with pet ether not Et2O which is quite soluble H2SO4), then H2O (care, as it may heat up in contact with conc H2SO4), dry (MgSO4), evaporate and distil it over Na. [S.rensen & S.rensen Acta Chem Scand 3 939 1949, Beilstein 1 III 570.]
Check Digit Verification of cas no
The CAS Registry Mumber 1921-70-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,9,2 and 1 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1921-70:
(6*1)+(5*9)+(4*2)+(3*1)+(2*7)+(1*0)=76
76 % 10 = 6
So 1921-70-6 is a valid CAS Registry Number.
InChI:InChI=1/C19H40/c1-16(2)10-7-12-18(5)14-9-15-19(6)13-8-11-17(3)4/h16-19H,7-15H2,1-6H3
1921-70-6Relevant articles and documents
Jain,Striha
, p. 4359 (1969)
Class II histocompatibility complex expression enhancing compound and preparation method and application thereof
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Paragraph 0099-0102, (2021/08/28)
The invention discloses a class II histocompatibility complex (MHC class II) expression enhancing compound and a preparation method and application thereof. Experiments prove that the compound has a remarkable class II histocompatibility complex expression enhancing effect, remarkable effect in enhancing class II histocompatibility complex tumor neoantigen presentation and promoting tumor tissue CD4 + T cell infiltration, and remarkable effect in inhibiting tumor growth when the compound is used independently or combined with existing immunotherapy means drugs.
A method for synthesizing basking shark alkane
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, (2017/08/23)
The present invention discloses a novel method for chemically synthesizing pristane with isophytol as a starting material. Isophytol is used, and pristane is prepared through oxidation, a methyl Grignard reaction, sulfonylation, halogenation and reduction. The method in the present invention, as compared with the conventional synthesizing method, adopts cheap raw materials, avoids high pressure hydrogenation reactions, and solves the problems of methyl migration caused by a dehydration reaction or isomerization caused by cyclization in the conventional synthesizing method. The method of the present invention is suitable for industrial production of pristane.
