2140-82-1Relevant academic research and scientific papers
Development of synthetic routes to D,L-α-tocopherol (vitamin E) from biologically produced geranylgeraniol
Hyatt, John A.,Kottas, Gregg S.,Effler, Janet
, p. 782 - 787 (2013/09/06)
The use of the biologically derived diterpene alcohol geranylgeraniol was explored as an alternative to petrochemical-based isophytol as a side-chain synthon for producing D,L-α-tocopherol. Two routes were studied, both of which begin with allylic epoxidation followed by olefin hydrogenation to give epoxyphytol. Epoxyphytol can be reduced with Red-Al to provide phytan-1,3-diol which upon acid-catalyzed condensation with trimethylhydroquinone gives vitamin E in fair yield. In a higher-yielding process, epoxyphytol was deoxygenated with methylrhenium trioxide/triphenylphosphine to generate a mixture of phytol and isophytol (> 90% yield from geranylgeraniol). This mixture can serve as a "plug-in" replacement for isophytol in the final step of the currently practiced vitamin E chemistry. The use of methylrhenium trioxide to catalyse dehydration of vinyl dialkyl carbinols to 1,3-dienes was also demonstrated.
Pyrolytic formation of C19 isoprenoid hydrocarbons from dihydrophytol: In relation to the genesis of pristane in petroleum
Ishiwatari, Mariko,Yamada, Keita,Ishiwatari, Ryoshi
, p. 206 - 207 (2007/10/03)
This study was concluded to elucidate a pathway for formation of C19 isoprenoid hydrocarbons (isops) in petroleum from chlorophylls. C19 isops are predominantly produced when dihydrophytol is heated at 320°C for a period ranging from 1 to 5 h under vacuum while C20 isops are predominantly produced when chlorophyll a or phytol is heated. A radical chain reaction of decomposition of dihydrophytol is proposed as plausible pathway for producing C19 isops.
