31376-66-6

Basic information

• Product Name: C₁₅H₁₄ClNO₂
• Synonyms: C₁₅H₁₄ClNO₂
• CAS NO: 31376-66-6
• Molecular Weight: 275.735
• Mol File: 31376-66-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₁₅H₁₄ClNO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₁₄ClNO₂(31376-66-6)
• EPA Substance Registry System: C₁₅H₁₄ClNO₂(31376-66-6)

Safety Data

• Hazardous Substances Data: 31376-66-6(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 19218-88-3 N-phenyl-4-chloroanthranilic acid 
• 74-88-4 methyl iodide 
• 13421-13-1 4-chloro-2-iodobenzoic acid 
• 936-08-3 2-bromo-4-chlorobenzoic acid 

Downstream Products

• 1428865-38-6 4-chloro-2-(methyl(phenyl)amino)benzaldehyde 
• 31376-67-7 C₁₄H₁₄ClNO 
• 58658-41-6 3-chloro-10-methylacridin-9(10H)-one 

Relevant articles and documents

Redox-neutral decarboxylative photocyclization of anthranilic acids

A mild metal-, catalyst-, and oxidant-free photoredox neutral system has been found to efficiently enable intramolecular decarboxylative cyclization of anthranilic acids. This facile protocol provides an alternative method for the synthesis of carbazoles. Mechanistic studies reveal a key photoinduced 6π-electrocyclization process and formic acid was released as the sole byproduct.

Sc(OTf)3-catalyzed dehydrogenative cyclization for synthesis of N-methylacridones

A novel method has been developed for the synthesis of substituted N-methylacridones from 2-(N-methyl-N-phenylamino)benzaldehydes via dehydrogenative cyclization. This transformation involves two primary processes: the aldehyde first coordinates with Sc(OTf)3 and induces the aromatic electrophilic substitution (SEAr) reaction to form the active intermediate N-methyl-acridin-9-ol, which is then quickly oxidized in situ to afford the acridones. Furthermore, the procedure involved is both environmental friendly and atom efficient; H2O is the only byproduct in this reaction.