1264670-41-8

Basic information

• Product Name: 1-methyl-5-(trifluoromethyl)-1H-indole
• Synonyms: 1-methyl-5-(trifluoromethyl)-1H-indole
• CAS NO: 1264670-41-8
• Molecular Formula: C10H8F3N
• Molecular Weight: 199.1724296
• Mol File: 1264670-41-8.mol
• Article Data: 7

Chemical Properties

• Melting Point: 72-73 °C
• Boiling Point: 250.0±35.0 °C(Predicted)
• Appearance: /
• Density: 1.24±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-methyl-5-(trifluoromethyl)-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-5-(trifluoromethyl)-1H-indole(1264670-41-8)
• EPA Substance Registry System: 1-methyl-5-(trifluoromethyl)-1H-indole(1264670-41-8)

Safety Data

• Hazardous Substances Data: 1264670-41-8(Hazardous Substances Data)

Usage

General Description

1-Methyl-5-(trifluoromethyl)-1H-indole is a chemical compound with the molecular formula C10H8F3N. It is a derivative of indole, a heterocyclic aromatic organic compound. This chemical is commonly used in the pharmaceutical industry as a building block for the synthesis of various biologically active compounds. It has also been studied for its potential anti-inflammatory and anti-cancer properties. Additionally, 1-methyl-5-(trifluoromethyl)-1H-indole has been investigated for its applications in the field of material science and organic electronics due to its unique electronic properties. However, due to its potential toxicity and hazardous nature, it is important to handle this chemical with care and follow proper safety protocols when working with it.

Upstream product

• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 192182-55-1 (1-methyl-1H-indol-5-yl)boronic acid 
• 100846-24-0 5-trifluoromethyl-1H-indole 
• 74-88-4 methyl iodide 
• 837392-62-8 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole 
• 13523-92-7 1-methyl-1H-indol-5-ol 

Relevant articles and documents

Cross-Coupling through Ag(I)/Ag(III) Redox Manifold

In ample variety of transformations, the presence of silver as an additive or co-catalyst is believed to be innocuous for the efficiency of the operating metal catalyst. Even though Ag additives are required often as coupling partners, oxidants or halide scavengers, its role as a catalytically competent species is widely neglected in cross-coupling reactions. Most likely, this is due to the erroneously assumed incapacity of Ag to undergo 2e? redox steps. Definite proof is herein provided for the required elementary steps to accomplish the oxidative trifluoromethylation of arenes through AgI/AgIII redox catalysis (i. e. CEL coupling), namely: i) easy AgI/AgIII 2e? oxidation mediated by air; ii) bpy/phen ligation to AgIII; iii) boron-to-AgIII aryl transfer; and iv) ulterior reductive elimination of benzotrifluorides from an [aryl-AgIII-CF3] fragment. More precisely, an ultimate entry and full characterization of organosilver(III) compounds [K]+[AgIII(CF3)4]? (K-1), [(bpy)AgIII(CF3)3] (2) and [(phen)AgIII(CF3)3] (3), is described. The utility of 3 in cross-coupling has been showcased unambiguously, and a large variety of arylboron compounds was trifluoromethylated via [AgIII(aryl)(CF3)3]? intermediates. This work breaks with old stereotypes and misconceptions regarding the inability of Ag to undergo cross-coupling by itself.

Site-Selective 1,1-Difunctionalization of Unactivated Alkenes Enabled by Cationic Palladium Catalysis

A palladium(II)-catalyzed 1,1-difunctionalization of unactivated terminal and internal alkenes via addition of two nucleophiles was developed using a cationic palladium(II) complex. The palladacycle generated in situ as a result of a regioselective addition of a nucleophile to the alkene can readily undergo regioselective β-hydride elimination and migratory insertion with a cationic palladium catalyst. The resulting η3-π-allyl palladium(II) complex is the key intermediate that reacts with a second nucleophile to furnish the desired 1,1-difunctionalization of the alkene. Under the optimized reaction conditions, a wide range of indoles and anilines add to alkene units of 3-butenoic or 4-pentenoic acid derivatives to afford the synthetically useful γ,γ- or δ,δ-difunctionalized products with excellent regiocontrol. Furthermore, by employing internal hydroxyl or acid groups and external carbon nucleophiles, this transformation enables unsymmetric 1,1-difunctionalization to forge challenging and important oxo quaternary carbon centers. Combining experiments and DFT calculations on the mechanism of the reaction is investigated in detail.

α7 NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS AND USES THEREOF - III

The present invention relates to chemical compounds useful in the positive modulation of the alpha 7 nicotinic acetylcholine receptor (α7 nAChR).